Development of Novel Separation Method Based on Specific Distribution Behavior of Fluidic Solvents in a Capillary Tube

我们研究了混合溶剂溶液在微空间中表现出的一种特定的微流体行为，称为管径向分布现象（TRDP）。在三元亲水/疏水有机溶剂、水表面活性剂、水离子液体和含氟/有机溶剂中观察到特定的流体行为。当混合均匀溶液在一定条件下进入微空间时，溶剂分子在微空间中呈放射状分布，形成具有动力学液-液界面的内外相。TRDP主要通过荧光显微镜、相图构建和溶质在毛细管中的洗脱行为来评估。基于TRDP的毛细管色谱，称为管径向分布色谱（TRDC），其中外相在层流条件下作为伪固定相，已被开发为TRDP的应用之一。我们还研究了基于trdp的提取、化学反应和混合过程，分别被称为管径向分布提取（TRDE）、管径向分布反应（TRDR）和管径向分布混合（TRDM）。本研究考察了TRDP、TRDC、TRDE、TRDR和TRDM的概念和实验结果。

We examined a specific microfluidic behavior exhibited by mixed-solvent solutions in a microspace, coined as the tube radial distribution phenomenon (TRDP). The specific fluidic behavior was observed in the following solution systems : ternary water-hydrophilic/hydrophobic organic solvents, water-surfactant、 water-ionic liquid, and fluorous/organic solvents. When the mixed homogeneous solutions were delivered into a microspace under certain conditions, the solvent molecules were radially distributed in the microspace, generating inner and outer phases with a kinetic liquid-liquid interface. The TRDP was fundamentally evaluated by fluorescence microscopy, phase diagrams construction, and the elution behaviors of solutes in a capillary tube. A TRDP-based capillary chromatography, referred to as tube radial distribution chromatography (TRDC), where the outer phase serves as a pseudo-stationary phase under laminar flow conditions, has been developed as one of the applications of TRDP. We have also investigated TRDP-based extraction, chemical reaction, and mixing processes, coined as tube radial distribution extraction (TRDE), tube radial distribution reaction (TRDR), and tube radial distribution mixing (TRDM), respectively. The concept and experimental findings regarding TRDP, TRDC, TRDE, TRDR, and TRDM were investigated through this study.