Development of Novel Separation Method Based on Specific Distribution Behavior of Fluidic Solvents in a Capillary Tube

基于毛细管中流体溶剂特定分布行为的新型分离方法的开发

• 批准号: 23550106
• 负责人: TSUKAGOSHI Kazuhiko
• 金额: $ 3.33万
• 依托单位: Doshisha University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23550106/
• 关键词: キャピラリーチューブ; クロマトグラフィー; 水-親水性/疎水性有機溶媒混合キャリア溶液; マイクロフロー; 層流; 相分離; 液-液界面; キャピラリークロマトグラフィー; 相図; 溶媒分子の分配; 管径方向分配現象; 管径方向分配クロマトグラフィー

We examined a specific microfluidic behavior exhibited by mixed-solvent solutions in a microspace, coined as the tube radial distribution phenomenon (TRDP). The specific fluidic behavior was observed in the following solution systems : ternary water-hydrophilic/hydrophobic organic solvents, water-surfactant、 water-ionic liquid, and fluorous/organic solvents. When the mixed homogeneous solutions were delivered into a microspace under certain conditions, the solvent molecules were radially distributed in the microspace, generating inner and outer phases with a kinetic liquid-liquid interface. The TRDP was fundamentally evaluated by fluorescence microscopy, phase diagrams construction, and the elution behaviors of solutes in a capillary tube. A TRDP-based capillary chromatography, referred to as tube radial distribution chromatography (TRDC), where the outer phase serves as a pseudo-stationary phase under laminar flow conditions, has been developed as one of the applications of TRDP. We have also investigated TRDP-based extraction, chemical reaction, and mixing processes, coined as tube radial distribution extraction (TRDE), tube radial distribution reaction (TRDR), and tube radial distribution mixing (TRDM), respectively. The concept and experimental findings regarding TRDP, TRDC, TRDE, TRDR, and TRDM were investigated through this study.

我们研究了一个特定的微流体行为所表现出的混合溶剂溶液在一个微空间，管径向分布现象（TRDP）。在水-亲水/疏水有机溶剂、水-表面活性剂、水-离子液体、氟/有机溶剂等三元溶液体系中观察到了特定的流体行为。当混合均匀的溶液在一定条件下被输送到微空间时，溶剂分子在微空间中呈放射状分布，产生具有动态液-液界面的内相和外相。通过荧光显微镜、相图构建和溶质在毛细管中的洗脱行为对TRDP进行了初步评价。基于TRDP的毛细管色谱，称为管径向分布色谱（TRDC），其中外相在层流条件下充当伪固定相，已被开发为TRDP的应用之一。我们还研究了基于TRDP的萃取、化学反应和混合过程，分别称为管径向分布萃取（TRDE）、管径向分布反应（TRDR）和管径向分布混合（TRDM）。通过本研究，对TRDP、TRDC、TRDE、TRDR和TRDM的概念和实验结果进行了研究。

项目成果

Michrochip Chromatography Using an Open-Tubular Microchannel and a Ternary Water-Acetonitrile-Ethyl Acetate Mixture Carrier Solution

使用开放管式微通道和三元水-乙腈-乙酸乙酯混合载体溶液的微芯片色谱法

• 发表时间: 2013
• 期刊: Journal of Separation Science
• 影响因子: 3.1
• 作者: Takafumi Matsuda;Kenichi Yamashita;Hideaki Maeda;Masahiko Hashimoto;and Kazuhiko Tsukagoshi
• 通讯作者: and Kazuhiko Tsukagoshi

Consideration of the Tube Radial Distribution of the Carrier Solvents in a Capillary Tube under Laminar Flow Conditions and Computer Simulation

层流条件下毛细管中载体溶剂的管径向分布的考虑及计算机模拟

• 发表时间: 2012
• 期刊: Analytical Sciences
• 影响因子: 1.6
• 作者: Naoya Jinno;Yuji Masuhara;Tomoya Kobayashi;Naoya Takahashi;Yusuke Tanigawa;Masahiko Hashimoto;and Kazuhiko Tsukagoshi
• 通讯作者: and Kazuhiko Tsukagoshi

STUDY OF OUTER PHASES IN CAPILLARY CHROMATOGRAPHY BASED ON TUBE RADIAL DISTRIBUTION OF CARRIER SOLVENTS UNDER LAMINAR FLOW CONDITIONS

层流条件下基于载体溶剂管径向分布的毛细管色谱外相研究

• DOI: 10.1080/10826076.2011.627599
• 发表时间: 2012
• 期刊: Journal of Liquid Chromatography & Related Technologies
• 影响因子: 1.3
• 作者: N. Jinno;Mari Murakami;Kiyoshi Mizohata;M. Hashimoto;K. Tsukagoshi
• 通讯作者: K. Tsukagoshi

Influence of Analyte Injection Volumes and Concentrations on Capillary Chromatography Based on Tube Radial Didstribution of Carrier Solvents under Laminar Flow Conditions

层流条件下分析物进样量和浓度对基于载体溶剂管径向分布的毛细管色谱的影响

• 发表时间: 2011
• 期刊: Chromatography
• 影响因子: 1.7
• 作者: Y. Tanigawa;N. Jinno;M. Hashimoto;K. Tsukagoshi
• 通讯作者: K. Tsukagoshi

Experiments and Considerations through the Phase Diagram in Open Tubular Capillary Chromatography Based on Tube Radial Distribution of Ternary Mixed Solvents Using a Fused-Silica Capillary Tube

基于使用熔融石英毛细管的三元混合溶剂的管径向分布的开管毛细管色谱中的相图实验和思考

• 发表时间: 2012
• 期刊: American Journal of Analytical Chemistry
• 作者: Yusuke Tanigawa;Naoya Jinno;Masahiko Hashimoto;Kazuhiko Tsukagoshi
• 通讯作者: Kazuhiko Tsukagoshi