Mechanism of selective transport in the retrograde traffic in the Golgi apparatus

对于细胞来说，新合成的蛋白质正确地靶向它们发挥功能的细胞器是至关重要的一步。我们进行了遗传和生化实验，以揭示ER-高尔基体之间的选择性膜运输机制，利用酿酒酵母，一个优秀的模式真核细胞。我们确定了Erv 41-Erv 46复合物的新货物，并发现了ER-高尔基体再循环膜蛋白，其精确功能以前未知作为货物受体蛋白的新候选者。

It is an essential step for cells that newly synthesized proteins are correctly targeted to the organelles where they function. We performed genetical and biochemical experiments to reveal the mechanisms for selective membrane transport between ER-Golgi using Saccharomyces cerevisiae, an excellent model eukaryotic cell. We identified a new cargo for the Erv41-Erv46 complex and found an ER-Golgi recycling membrane protein whose precise function was previously unknown as a new candidate of a cargo receptor protein.