Development of the new treatment, prophylaxis of the phylum Apicomplexa

开发新的治疗方法，预防顶复门

• 批准号: 23580445
• 负责人: SASAI Kazumi
• 金额: $ 3.41万
• 依托单位: Osaka Prefecture University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580445/
• 关键词: Apicomplexa; Apical complex; モノクローナル抗体; 感染防御; Cryptosporidium; apical complex; Elongation factor 1α; chicken mAB; マラリア; 侵入抑制; 交差性; Eimeria tenella; Cryptosporidium parvum; Plasmodium vinckei; 鶏型モノクローナル抗体; 抗原解析

The antigens in apical complex of Cryptosppridium parvum and Plasmodium berghei recognized were analyzed by monoclonal antibody (mAB) .From these results, the possibility that EF-1a played the role that was important to the host cells invasion due to the parasitic worm was suggested.Thus, the possibility that the antigen which mAB recognized was the antigen which could become a vaccine candidate for the cryptosporidiosis and Malaria was suggested.

用单克隆抗体（mAB）分析了隐孢子虫和伯氏疟原虫顶端复合体识别的抗原，提示EF-1a可能在隐孢子虫入侵宿主细胞中起重要作用，从而提示mAB识别的抗原有可能成为隐孢子虫病和疟疾疫苗候选抗原。

项目成果

Infectivity of Cryptosporidiumandersoni Kawatabi type relative to thesmall number of oocysts in immunodeficient and immunocompetent neonatal and adult mice

安氏隐孢子虫川田型相对于免疫缺陷和免疫功能正常的新生和成年小鼠中少量卵囊的感染性

• DOI: 10.1016/j.parint.2012.11.001
• 发表时间: 2013
• 期刊: Parasitol Int.2013
• 作者: Nagano-Koyashiki S;Matsubayashi M(CA);Kimata I;Furuya M;Tani H;Sasai K
• 通讯作者: Sasai K