The elucidation of central chemosensitive respiratory regulation by TRP channels expressed in glial cell.

脑干髓质的中枢化学敏感呼吸调节在维持血气和pH稳态中起重要作用。我们报道了瞬时受体电位（TRP）通道家族参与了髓质胶质细胞的高碳酸钙反应。为了确定TRP通道亚型作为中心化感分子，我们检测了TRP通道家族在髓质胶质细胞中的表达模式。TRP-X亚型通道在髓质胶质细胞中表达最高。与野生型小鼠相比，8%CO2对TRP-X敲除小鼠通气反应的影响减弱。这些结果表明，TRP-X通道参与中枢化学敏感呼吸调节。

The central chemosensitive respiratory regulation in medulla of brainstem is important in the maintenance of blood gas and pH homeostasis. We reported that transient receptor potential (TRP) channel family was involved in hypercapnic Ca responses in medullary glial cells. To identify the subtype of the TRP channels as central chemosensing molecules, we detected the expression pattern of TRP channel family in medullary glial cells. TRP-X subtype channel is highest expression in medullary glial cells. In comparison with wild-type mice, the effects of ventilation response to 8%CO2 on TRP-X knockout mice attenuated. These results suggest that the TRP-X channel is involved in the central chemosensitive respiratory regulation.