Regulation of microRNA by stimulation of growth factors in various cancer cells

miR-200 c和miR-27 b可能分别在ZEB 1介导的EMT和ECM降解以及ST-14/matriptase介导的HGF自激活中发挥重要作用。 这些由HGF直接调控的microRNA表达的改变可能通过调节HGF诱导的功能分子的翻译而促进HNSCC的进行性和侵袭性特征。 我们还证实了miR-182的表达依赖于癌症分级，即使在前列腺癌的相同Gleason模式4中。 活检样本中miR-182的表达与Gleason分级系统相关，可能有助于更准确的术前癌症风险评估。

MicroRNAs miR-200c and miR-27b, both of which were down-regulated by HGF stimulation in cultured human head and neck squamous carcinoma cells (HNSCC), might play an important role in EMT mediated by ZEB1 and ECM degradation and HGF auto-activation mediated by ST-14/matriptase, respectively. Altered expression of these microRNAs directly regulated by HGF might contribute enhanced progressive and invasive characteristics of HNSCC by regulating the translation of HGF-induced functional molecules. We also confirmed that the expression of miR-182 depends on the cancer grade even in same Gleason pattern 4 of prostate cancer. Expression of miR-182 associated with Gleason grading system in biopsy sample may contribute to more accurate preoperative cancer risk evaluation.