Studies on fever with unknown origin (FUO0 in South and South East Asia

不明原因发烧的研究（南亚和东南亚的 FUO0

• 批准号: 23590770
• 负责人: MORIMATSU Kumiko
• 金额: $ 3.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590770/
• 关键词: ハンタウイルス感染症; レプトスピラ; HEV; 不明熱; ハンタウイルス; レプトスピラ症; SFTS; デングウイルス; げっ歯類; レプトスピラ症状; デング熱; チクングニア; レジオネラ

The investigation of hantavirus-associated infectious diseases in Southeast Asia and South Asia had been conducted. Throughout the investigation, many examples of fever of unknown origin (FUO) were found from febrile diseases. In this report, it aimed to clarify FUO in this region. Febrile patient sera (not dengue fever and a flu victim) and wild rodent sera as a career of infectious agents conducted investigation of causative agent of febrile illness in Vietnam and Sri Lanka. Finally, it was suggested that seropositive cases against pathogenic organs, such as hepatitis E virus (HEV), leptospira, and hantaviruses are found from a part of FUO patient. Furthermore, it was shown that rodents in both countries also possessed these agents. Therefore rodents were able to be sources of these zoonotic agents.

对东南亚和南亚地区的汉坦病毒相关传染病进行了调查。在整个调查过程中，发现了许多原因不明的发热(FUO)病例，这些病例都是由发热性疾病引起的。在这份报告中，它旨在澄清这一地区的不明飞行物。以发热病人血清(非登革热和流感患者)和野生啮齿动物血清为职业感染者，对越南和斯里兰卡的发热病原进行了调查。提示部分FUO患者存在戊型肝炎病毒(HEV)、钩端螺旋体、汉坦病毒等致病器官血清阳性病例。此外，研究还表明，这两个国家的啮齿动物也拥有这些制剂。因此，啮齿动物能够成为这些人畜共患病病原体的来源。

项目成果

Application of Truncated Nucleocapsid Protein (N) for Serotyping ELISA of Murinae-Associated Hantavirus Infection in Rats

截短核衣壳蛋白 (N) 在大鼠鼠相关汉坦病毒感染血清分型 ELISA 中的应用

• 发表时间: 2012
• 期刊: J Vet Med Sci
• 影响因子: 1.2
• 作者: Yasuda SP;Yoshimatsu K;Koma T;Shimizu K;Endo R;Isozumi R;Arikawa J
• 通讯作者: Arikawa J

Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection

• DOI: 10.1016/j.jviromet.2012.06.006
• 发表时间: 2012-10-01
• 期刊: JOURNAL OF VIROLOGICAL METHODS
• 影响因子: 3.1
• 作者: Koma, Takaaki;Yoshimatsu, Kumiko;Arikawa, Jiro
• 通讯作者: Arikawa, Jiro

Susceptibility of laboratory rats against genotypes 1, 3, 4, and rat hepatitis E viruses

• DOI: 10.1016/j.vetmic.2012.12.014
• 发表时间: 2013-04-12
• 期刊: VETERINARY MICROBIOLOGY
• 影响因子: 3.3
• 作者: Li, Tian-Cheng;Yoshizaki, Sayaka;Wakita, Takaji
• 通讯作者: Wakita, Takaji

Development of an Immunochromatography Strip Test for Detecting Anti-hantavirus Antibody in Rodent and Human Sera by Using an N-terminal Common Antigenic Site of Hantavirus N protein

利用汉坦病毒 N 蛋白 N 端共同抗原位点开发免疫层析试纸条检测啮齿动物和人类血清中的抗汉坦病毒抗体

• 发表时间: 2013
• 作者: Arikawa J;Amada T;Yoshimatsu K;Hayashimoto N;Koma T;Shimizu K;Gamage CD;Shiokawa K;Nishio S;Ahlm C;Takakura A
• 通讯作者: Takakura A

Application of recombinant LigA and LipL32 to the lateral flow immunoassay for the detection of pathogenic Leptospira spp. specific IgG in rodent sera

重组LigA和LipL32在侧流免疫分析中检测致病性钩端螺旋体的应用。

• 发表时间: 2013
• 作者: Shiokawa K;Gamage CD;Koizumi N;Nishio S;Koarashi Y;Tsuda Y;Shimizu K;Yoshimatsu K;Arikawa J
• 通讯作者: Arikawa J