Studies on fever with unknown origin (FUO0 in South and South East Asia

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The investigation of hantavirus-associated infectious diseases in Southeast Asia and South Asia had been conducted. Throughout the investigation, many examples of fever of unknown origin (FUO) were found from febrile diseases. In this report, it aimed to clarify FUO in this region. Febrile patient sera (not dengue fever and a flu victim) and wild rodent sera as a career of infectious agents conducted investigation of causative agent of febrile illness in Vietnam and Sri Lanka. Finally, it was suggested that seropositive cases against pathogenic organs, such as hepatitis E virus (HEV), leptospira, and hantaviruses are found from a part of FUO patient. Furthermore, it was shown that rodents in both countries also possessed these agents. Therefore rodents were able to be sources of these zoonotic agents.