To overcome intractable chronic cough: disclosure of mechanism of cough response to bronchoconstiction to conrol of the cough

攻克顽固性慢性咳嗽：揭示支气管收缩咳嗽反应机制控制咳嗽

• 批准号: 23591142
• 负责人: FUJIMURA Masaki
• 金额: $ 3.24万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591142/
• 关键词: 慢性咳嗽; 咳喘息; 気管支平滑筋収縮; 気管支平滑筋; 難治性; 咳嗽反応

Basic study: Beta2-agonists abolished both the methacholine-induced bronchoconstriction and cough. Capsaicin desensitization had no effect on the bronchoconstriction or the number of coughs. Moguisteine inhibited the number of coughs but not the bronchoconstriction. It is concluded that bronchoconstriction causes cough via RARs, but not C-fibers. Furthermore, prostaglandin E2 takes a role to enhance the methacholine-induced cough response as protection of bronchoconstriction.Clinical study: Cough response to bronchoconstriction induced by Meth was heightened in cough variant asthma patients. The increased cough response recovered to normal range after treatment. Thus, we identified heightened cough response to bronchoconstriction as a fundamental physiologic feature of cough variant asthma. Sensitivity and specificity of cough responsiveness to Mch for discrimination of cough variant asthma from chronic non-productive cough were 81.0% and 89.7%, respectively.

基础研究：β 2激动剂可消除甲基苯丙胺引起的支气管收缩和咳嗽。辣椒素脱敏对支气管收缩和咳嗽次数无影响。莫古斯汀抑制咳嗽次数，但对支气管收缩无抑制作用。结论支气管收缩通过RARs引起咳嗽，而不是通过c -纤维引起咳嗽。此外，前列腺素E2可增强甲基苯丙胺诱导的咳嗽反应，保护支气管收缩。临床研究：咳嗽变异性哮喘患者对甲基苯丙胺所致支气管收缩的咳嗽反应增高。治疗后咳嗽反应恢复到正常范围。因此，我们确定支气管收缩引起的咳嗽反应增强是咳嗽变异性哮喘的基本生理特征。咳嗽反应性Mch对区分咳嗽变异性哮喘和慢性非生产性咳嗽的敏感性和特异性分别为81.0%和89.7%。

项目成果

非小細胞肺癌外来化学療法患者のQOLに対する補中益気湯の効

Hochuekkito对非小细胞肺癌门诊化疗患者生活质量的影响

• 发表时间: 2013
• 期刊: 癌と化学療法
• 作者: 石浦嘉久;山本宏樹;芝靖貴;寺崎靖;石田陽一;谷川二美子;早瀬秀子;丸山和美;小幡智恵美;石川見佳;廣上典和;笠原寿郎;藤村政樹
• 通讯作者: 藤村政樹

好酸球と咳. 特集：長引く咳の診断と治療.

嗜酸性粒细胞与咳嗽。特色：持续性咳嗽的诊断和治疗。

• 发表时间: 2013
• 期刊: 日本医師会雑誌
• 作者: Sato T;Liu X;Basma H;Togo S;Sugiura H;Nelson A;Nakanishi M;Kanaji N;Wang X;Kim M;Li Y;Michalski J;Farid M;Sharp JG;Rennard SI;久保惠嗣;藤村政樹
• 通讯作者: 藤村政樹

非小細胞肺癌外来化学療法患者のQOLに対する補中益気湯の効果

Hochuekkito对非小细胞肺癌门诊化疗患者生活质量的影响

• 发表时间: 2013
• 期刊: 癌と化学療法
• 作者: 石浦嘉久;山本宏樹;芝靖貴;寺崎靖;石田陽一;谷川二美子;早瀬秀子;丸山和美;小幡智恵美;石川見佳;廣上典和;笠原寿郎;藤村政樹
• 通讯作者: 藤村政樹

Frequency of Persistent Cough and Trends in Seeking Medical Care and Treatment -- Results of an Internet Survey in Japan

持续咳嗽的频率以及就医的趋势——日本的一项网络调查结果

• 发表时间: 2012
• 期刊: Allergology International
• 影响因子: 6.8
• 作者: Matsunaga K;Hirano T;Akamatsu K;Koarai A;Sugiura H;Minakata Y;Ichinose M;Fujimura M
• 通讯作者: Fujimura M

Predicting performance of cough reflex sensitivity, exhaled nitric oxide (eNO) and bronchial responsiveness for efficacy of bronchodilator therapy on isolated chronic non-productive cough

预测咳嗽反射敏感性、呼出一氧化氮 (eNO) 和支气管反应性，以评估支气管扩张剂治疗孤立性慢性干咳的疗效

• 发表时间: 2011
• 作者: Fujimura M;Ohkura N;Tokuda A;Waseda Y
• 通讯作者: Waseda Y