权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Mechanisms of heightened airway cough receptor sensitivity in eosinophilic bronchitis (atopic cough : eosinophilic bronchitis without asthma).

嗜酸性粒细胞性支气管炎气道咳嗽受体敏感性升高的机制（特应性咳嗽：不伴哮喘的嗜酸性粒细胞性支气管炎）。

基本信息

批准号：
04807055
负责人：
FUJIMURA Masaki
金额：
$ 1.28万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

1.Clinical study on chronic nonproductive cough(1) A new clinical entity named as "ATOPIC COUGH" has been proposed, which is different from cough variant asthma.(2) Bronchodilator therapy is ineffective, bronchial responsiveness to methacholine is within normal range, and airway cough receptor sensitivity to inhaled capsaicin is heightened in atopic cough.(3) The histologic feature is considered to be large airway eosinophilic inflammation according to the following findings : no eosinophils in bronchoalveolar lavage fluid or bronchial lavage fluid, small number of eosinophils in biopsied bronchial specimens, and almost same number of eosinophils in hypertonic saline-induced sputum as bronchial asthma.(4) Histamine Hl-antagonists and steroids are effective for the treatment of atopic cough.2.Animal experiment on eosinophilic bronchitis(1) Eosinophilic bronchitis model of guinea pigs was successfully developed by intranasal administration of polymycin B twice a week for 3 weeks.(2) Airway cough receptor sensitivity to inhaled capsaicin was heightened but bronchial responsiveness to inhaled histamine was not increased in this model.(3) A neuropeptide inhibitor (FK-224) and a thromboxane receptor antagonist (S-1452) but not a beta2-agonist (procaterol) significantly reduced the heightened airway cough receptor sensitivity.(4) A histamine Hl-antagonist (azelastin) significantly suppressed the heightened airway cough receptor sensitivity.3.ConclusionFrom these results, it is suggested that there are at least 2 different mechanisms for the pathophysiology of persistent nonproductive cough (pathological cough) : heightened airway cough receptor sensitivity induced by eosinophilic inflammation of the large airway in atopic cough and bronchoconstriction based on bronchial hyperresponsiveness induced by eosinophilic inflammation of the central to peripheral airways in cough variant asthma.

1.慢性干咳的临床研究（1）提出了一个新的临床实体--特发性咳嗽（ATOPIC COUGH），它不同于咳嗽变异性哮喘（CVA）。(2)支气管扩张剂治疗无效，支气管对乙酰甲胆碱的反应性在正常范围内，气道咳嗽受体对吸入辣椒素的敏感性在特应性咳嗽中升高。(3)根据以下结果，组织学特征被认为是大气道嗜酸性粒细胞炎症：支气管肺泡灌洗液或支气管灌洗液中没有嗜酸性粒细胞，活检支气管标本中有少量嗜酸性粒细胞，高渗盐水诱导痰中的嗜酸性粒细胞数量与支气管哮喘几乎相同。(4)组胺H1受体拮抗剂和激素类药物是治疗特应性咳嗽的有效药物。2.嗜酸粒细胞性支气管炎的动物实验（1）采用多霉素B鼻腔给药，每周2次，连续3周，成功地建立了豚鼠嗜酸粒细胞性支气管炎模型。(2)在该模型中，气道咳嗽受体对吸入辣椒素的敏感性升高，但支气管对吸入组胺的反应性没有增加。(3)神经肽抑制剂（FK-224）和血栓烷受体拮抗剂（S-1452）可显著降低气道咳嗽受体敏感性升高，但β 2-激动剂（丙卡特罗）无此作用。(4)一种组胺H1拮抗剂，结论持续性干咳的病理生理学机制至少有2种不同的机制（病理性咳嗽）：特应性咳嗽中大气道嗜酸性粒细胞炎症诱导的气道咳嗽受体敏感性升高和基于支气管高反应性诱导的支气管收缩咳嗽变异性哮喘的中枢至外周气道嗜酸性粒细胞炎症。