To overcome the intractable chronic cough : mechanism of cough and development of therapy

克服顽固性慢性咳嗽：咳嗽机制及治疗进展

• 批准号: 20590916
• 负责人: FUJIMURA Masaki
• 金额: $ 2.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590916/
• 关键词: 慢性咳嗽; 難治性; 咳嗽発生機序; 知覚神経; 平滑筋収縮; 平滑筋

It has been disclosed that there are at least two pathway of cough reflex : (1) increased cough receptor sensitivity (atopic cough) or hyper-stimulation to cough receptors (sinobronchial syndrome) which are present in inter- and sub epithelium of airway, (2) increased response of sensory nerve endings (Adelta-fibers) in intra- and peri-smooth muscle layer to the smooth muscle contraction (cough variant asthma) or hyper-stimulation (strong smooth muscle contraction) to the nerve endings.

已经公开了存在至少两种咳嗽反射途径：（1）咳嗽受体敏感性增加（特应性咳嗽）或过度刺激咳嗽受体（窦支气管综合征），其存在于气道的上皮间和上皮下，（2）感觉神经末梢反应增强（Adelta-纤维）对平滑肌收缩（咳嗽变异性哮喘）或对神经末梢的过度刺激（强烈的平滑肌收缩）起作用。

项目成果

Exhaled nitric oxide (NO) levels in patients with atopic cough and cough variant asthma

特应性咳嗽和咳嗽变异性哮喘患者呼出一氧化氮 (NO) 水平

• 发表时间: 2008
• 期刊: Respirology 13 (3)
• 作者: Fujimura M;et al
• 通讯作者: et al

Symposium "Cough in the Asia Pacific region" Eosinophilic bronchitis

研讨会“亚太地区的咳嗽”嗜酸性支气管炎

• 发表时间: 2008
• 作者: Ohkura N;Fujimura M;Tokuda A;Katayama N;Abo M;Nakao S.;Fujimura M
• 通讯作者: Fujimura M

慢性咳嗽を診る:症例ら学ぶ(総論:慢性咳嗽の定義と基礎病態)(藤村政樹編集)(改訂版)

慢性咳嗽的诊断：从病例中学习（概述：慢性咳嗽的定义和基本病理）（藤村正树主编）（修订版）

• 发表时间: 2010
• 作者: Ohkura N;Fujimura M;Tokuda A;Katayama N;Abo M;Nakao S.;Fujimura M;藤村政樹;藤村政樹;藤村政樹;藤村政樹;藤村政樹;藤村政樹;藤村政樹;藤村政樹;藤村政樹
• 通讯作者: 藤村政樹

Ventilatory impairment detection based on distribution of respiratory-induced changes in pixel values in dynamic chest radiography: a feasibility study

• DOI: 10.1007/s11548-010-0491-y
• 发表时间: 2011-01-01
• 期刊: INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
• 影响因子: 3
• 作者: Tanaka, Rie;Sanada, Shigeru;Matsui, Osamu
• 通讯作者: Matsui, Osamu

Bronchoconstriction-triggered Cough Is Impaired in Typical Asthmatics

典型哮喘患者的支气管收缩引发的咳嗽受到损害

• DOI: 10.3109/02770900903362650
• 发表时间: 2010
• 期刊: Journal of Asthma
• 影响因子: 1.9
• 作者: N. Ohkura;M. Fujimura;A. Tokuda;Y. Nakade;M. Nishitsuji;M. Abo;N. Katayama
• 通讯作者: N. Katayama