Treating strategie for CKD with Klotho as a targetting molecule

点击翻译按钮获取中文摘要

Defects in Klotho gene expression in mice result in a syndrome resembling human aging that resembling with pathophysiology of chronic kidney disease (CKD). It has been clarified that membrane Klotho functions as a co-receptor for fibroblast growth factor 23 (FGF23) that regulate phosphate metabolism. Renal expression of the Klotho gene is markedly suppressed in CKD. Since renal fibrosis is a major risk factor for progression of CKD, renal interstitial fibrosis and Klotho expression should be correlated with each other. In this project, we explored the role and biological properties of Klotho, and especially focused on the phosphate metabolism, anti-fibrotic mechanism and clinical relevance of Klotho by measuring serum Klotho level in CKD. A reduction of Klotho expression aggravates renal interstitial fibrosis and that fibrosis-related factors regulate Klotho expression, making a vicious spiral in CKD. Thus, Klotho molecule is a targeting molecule in therapeutic strategy in CKD.