A role of BMP on the development of glomerular capillary tufts

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We established the transgenic mouse line (Podocine-rtTA; TetO-Noggin), in which Noggin, Bmp inhibitor, was selectively expressed only in the podocytes under the control of Dox. We then analyzed the adult transgenic mice with or without Dox for 3 months. Podocine-rtTA; TetO-Noggin with Dox showed a reduced expression of TG-lectin expression in proximal tubules, interstitial edema and a decrease in proximal tubular cells positive for phosphorylated Smad1/5/8. In contrast, the morphology of glomerulus appeared normal. It has been shown that BMP7-receptor, but not BMP per se, is not expressed in proximal tubules. Conditional knockout of Bmp7 in podoccytes has been reported to lead to a defect in proximal tubule development during embryonic stage. In conjunction with these findings, we assume that, in adulthood also, the podocyte injury cause not only the development of glomerulosclerosis, but also a damage in proximal tubules via a decrease of BMP expression.