Analysis of boold-brain barrier breakdown in the early stage of acute encephalopathy
Analysis of boold-brain barrier breakdown in the early stage of acute encephalopathy
批准号:
23591509
负责人:
ASAI Kiyofumi
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
To understand the pathophysiological mechanism of acute encephalopathy, and analyze the aggregative action of diclofenac sodium (DCF) on acute encephalopathy, we stimulated primary cultured rat astrocytes and microglia with IL-1beta;, TNF-alpha and IFN-gamma. The expression of iNOS and AQP4 and the production of NO were upregulated in astrocytes and the expression of iNOS and the activities of phagocytosis were increased in microglia. The addition of DCF highly enhanced the expression of iNOS and AQP4, and the activities of phagocytosis. This enhancement may explain the significantly increased mortality rates in acute encephalopathy patients treated with DCF.
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ES細胞特異的Ras, ERasはEpithelial-Mesenchymal transitionを介して胃癌の肝転移を促進する。
ES细胞特异性Ras和ERas通过上皮间质转化促进胃癌肝转移。
DOI:
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发表时间:
2011
期刊:
影响因子:
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[柳久美子, 要匡, 小口良子, 當間隆也, 泉川良範, 吉浦孝一郎, 新川詔夫, 成富研二, 片岡洋望]
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2011
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A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis
新型肠内饮食 MHN-02 含有丰富的抗氧化剂和乳清肽,可预防四氯化碳诱发的肝炎
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发表时间:
2011
期刊:
JPEN J Parenter Enteral Nutr
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[Takayanagi T, Sasaki H, Kawashima A, Mizuochi Y, Hirate H, Sugiura T, Azami T, Asai K, Sobue K]
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水チャネル「アクアポリン」の発現と機能−整形外科疾患との関わりについて−
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发表时间:
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发表时间:
2012
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[青山峰芳, 加藤晋, 垣田博樹, 浅井隼人, 長屋嘉顕, 浅井清文]
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共 25 条
Mechanism of breakdown of blood-brain barrier accompanied with viral encephalopathy
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批准号:20591228
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2008
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负责人:ASAI Kiyofumi
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依托单位:
Analysis of cell signaling of Glia Maturation Factor-beta and-gamma in the central nervous system
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批准号:17591105
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:ASAI Kiyofumi
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依托单位:
Analysis of cell signaling of Glia Maturation Factor -beta and -gamma in the central nervous system
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批准号:15591121
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:ASAI Kiyofumi
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依托单位:
Function of GMFB and GMFG in brain development
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批准号:12670767
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2000
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负责人:ASAI Kiyofumi
-
依托单位:
Application of in vitro Blood-Brain Barrier model for assessment of drug delivery to central nervous system.
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批准号:11557107
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.19万
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财政年份:1999
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负责人:ASAI Kiyofumi
-
依托单位:
Roles of neurotrophic factors derived from astrocyte in neuronal development
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批准号:10670747
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1998
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负责人:ASAI Kiyofumi
-
依托单位:
Regional differences of astrocytic function
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批准号:10214202
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas (B)
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资助金额:$18.62万
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财政年份:1998
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负责人:ASAI Kiyofumi
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依托单位:
海外基金