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Analysis of boold-brain barrier breakdown in the early stage of acute encephalopathy

Analysis of boold-brain barrier breakdown in the early stage of acute encephalopathy
急性脑病早期血脑屏障破坏分析
批准号:
23591509
负责人:
ASAI Kiyofumi
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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英文摘要
To understand the pathophysiological mechanism of acute encephalopathy, and analyze the aggregative action of diclofenac sodium (DCF) on acute encephalopathy, we stimulated primary cultured rat astrocytes and microglia with IL-1beta;, TNF-alpha and IFN-gamma. The expression of iNOS and AQP4 and the production of NO were upregulated in astrocytes and the expression of iNOS and the activities of phagocytosis were increased in microglia. The addition of DCF highly enhanced the expression of iNOS and AQP4, and the activities of phagocytosis. This enhancement may explain the significantly increased mortality rates in acute encephalopathy patients treated with DCF.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [柳久美子, 要匡, 小口良子, 當間隆也, 泉川良範, 吉浦孝一郎, 新川詔夫, 成富研二, 片岡洋望]
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发表时间: 2011
期刊:
影响因子: --
作者: [Chiharu Hidaka, Shinichi Mitsui, Kazunari Yuri, 青山峰芳]
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A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis
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DOI: --
发表时间: 2011
期刊: JPEN J Parenter Enteral Nutr
影响因子: --
作者: [Takayanagi T, Sasaki H, Kawashima A, Mizuochi Y, Hirate H, Sugiura T, Azami T, Asai K, Sobue K]
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水チャネル「アクアポリン」の発現と機能−整形外科疾患との関わりについて−
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发表时间: 2012
期刊:
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25
    Mechanism of breakdown of blood-brain barrier accompanied with viral encephalopathy
    • 批准号:
      20591228
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2008
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      17591105
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
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    • 财政年份:
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    • 批准号:
      15591121
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
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    • 财政年份:
      2003
    • 负责人:
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    • 批准号:
      12670767
    • 项目类别:
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    • 资助金额:
      $2.43万
    • 财政年份:
      2000
    • 负责人:
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    • 依托单位:
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