A diagnostic method of focal segmental glomerulosclerosis by low vacuum scanning electron microscopy

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We observed renal biopsy paraffin sections of nephrotic syndrome (NS) patients by low vacuum scanning electron microscopy (LVSEM). The round-shaped podocyte cell bodies were noted especially in steroid-resistant NS specimens compared with steroid-sensitive NS. The morphological changes of podocytes cell bodies may be related to the decreased expressions of nephrin or podocin in glomeruli. An application of a LVSEM to renal biopsy paraffin sections of NS patients was useful to classify focal segmental glomerulosclerosis (FSGS) specimens into the variants of the Columbia pathological classification. we considered that the evaluation method by LVSEM is probably useful the early histological diagnosis of FSGS.