The correlation between FDG uptake and various oncogenes expression in pancreas cancer

我们研究了胰腺癌中FDG摄取指数（SUVmax）、MRI扩散指数（ADC）与各种癌基因表达的相关性。此外，我们评估了这些参数与预后的关系。SUVmax与EGFR、Ki-67、CDH13、VEGFA、p53呈弱正相关。复发组的SUV max值明显高于非复发组。ADC平均水平复发组明显降低。复发组的CDH13和VEGFA值均明显升高。在胰腺癌中，参与肿瘤血管增殖和组织粘附的基因表达是重要的预后因素。此外，SUV max和ADC平均值是预测预后的重要影像生物标志物。

We examined correlation among FDG uptake indices (SUVmax), MRI diffusion index(ADC) and various oncogenes expression in pancreas cancer. In addition, we evaluated the association those parameters and prognoses.Positive weak correlations were noted among SUVmax and EGFR, Ki-67, CDH13, VEGFA, p53.The value of SUV max was significantly higher in the recurrent group compared with that of the non-recurrence group. As for ADC mean level, it was significantly lower in the recurrent group. Both CDH13 and VEGFA demonstrated significantly higher values in the recurrent group.In pancreas cancer, gene expressions such as involving in tumor-vascular proliferation and tissue adhesion were the important prognostic factor.In addition, both SUV max and ADC mean were important imaging biomarker for predicting prognosis.