The correlation between FDG uptake and various oncogenes expression in pancreas cancer

胰腺癌FDG摄取与多种癌基因表达的相关性

• 批准号: 23591782
• 负责人: NAGAMACHI SHIGEKI
• 金额: $ 3.33万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591782/
• 关键词: すい臓がん; 癌遺伝子; RT-PCR; FDG-PET; ADC; prognosis; 膵臓癌; FDG-PET/CT; 予後; SUVmax; 癌遺伝子発現

We examined correlation among FDG uptake indices (SUVmax), MRI diffusion index(ADC) and various oncogenes expression in pancreas cancer. In addition, we evaluated the association those parameters and prognoses.Positive weak correlations were noted among SUVmax and EGFR, Ki-67, CDH13, VEGFA, p53.The value of SUV max was significantly higher in the recurrent group compared with that of the non-recurrence group. As for ADC mean level, it was significantly lower in the recurrent group. Both CDH13 and VEGFA demonstrated significantly higher values in the recurrent group.In pancreas cancer, gene expressions such as involving in tumor-vascular proliferation and tissue adhesion were the important prognostic factor.In addition, both SUV max and ADC mean were important imaging biomarker for predicting prognosis.

我们检查了FDG摄取指数（SUVMAX），MRI扩散指数（ADC）和胰腺癌中各种癌基因表达之间的相关性。此外，我们评估了这些参数和预后的关联。在Suvmax和EGFR，Ki-67，CDH13，VEGFA，VEGFA，p53中注意到了阳性弱相关性。相比，复发组的SUV最大值的值显着更高。至于ADC的平均水平，复发组的较低。 CDH13和VEGFA在复发组中均显示出明显更高的值。在胰腺癌中，基因表达（例如参与肿瘤 - 血管增殖和组织粘附）是重要的预后因素。在SUV Max和ADC平均值中，均为预测预测的重要成像生物标志物。