The correlation between FDG uptake and various oncogenes expression in pancreas cancer

胰腺癌FDG摄取与多种癌基因表达的相关性

• 批准号: 23591782
• 负责人: NAGAMACHI SHIGEKI
• 金额: $ 3.33万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591782/
• 关键词: すい臓がん; 癌遺伝子; RT-PCR; FDG-PET; ADC; prognosis; 膵臓癌; FDG-PET/CT; 予後; SUVmax; 癌遺伝子発現

We examined correlation among FDG uptake indices (SUVmax), MRI diffusion index(ADC) and various oncogenes expression in pancreas cancer. In addition, we evaluated the association those parameters and prognoses.Positive weak correlations were noted among SUVmax and EGFR, Ki-67, CDH13, VEGFA, p53.The value of SUV max was significantly higher in the recurrent group compared with that of the non-recurrence group. As for ADC mean level, it was significantly lower in the recurrent group. Both CDH13 and VEGFA demonstrated significantly higher values in the recurrent group.In pancreas cancer, gene expressions such as involving in tumor-vascular proliferation and tissue adhesion were the important prognostic factor.In addition, both SUV max and ADC mean were important imaging biomarker for predicting prognosis.

我们检验了胰腺癌中FDG摄取指数(SUVmax)、MRI扩散指数(ADC)和各种癌基因表达之间的相关性。SUVmax与EGFR、Ki-67、CDH13、VEGFA、p53呈弱相关，复发组SUVmax显著高于未复发组。复发组ADC值明显低于复发组。CDH13和VEGFA在复发性胰腺癌中均有较高的表达，参与肿瘤血管增殖、组织粘连等基因表达是影响胰腺癌预后的重要因素，SUV max和ADC均值是预测预后的重要影像生物学指标。