Regulation of reactive oxygen species induced by heavy-ion (carbon) beam; Pursuing the sophistication of heavy-ion cancer therapy

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Density of radiation induced hydroxyl radical could be measured by electron paramagnetic resonance (EPR) spin trapping method. Superoxide could be measured by EPR spin probing method. Hydrogen peroxide could also be measured by EPR spin probing method. Results from those measurements gave a prediction that the very dense hydroxyl radical generation by high LET radiation can not be regulated by biologically available antioxidants concentration. Other reactive oxygen species including low density hydroxyl radical could possibly be regulated or partly regulated using antioxidants.Inhibitory effect of TEMPOL to the radiation induced fibrosis caused by carbon-ion beam on mouse leg muscle was tested. Administration of TEMPOL dose affect to the fibrosis contrary to expectations.