The exploration of novel therapeutic target in gastric cancer by comprehensive tyrosine-kinase analysis

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We analyzed the comprehensive gene expression in gastric cancer to explore the novel tyrosine-kinase related to the development of cancer, especially peritoneal dissemination. Then the novel and well-known tyrosine-kinases; KSR1 and MEK, Her2 and FGFR1 were identified. KSR1 is a tyrosine-kinase that functions as positive regulator of Ras pathway, and associated with the cell motility, invasion and peritoneal dissemination. FOXM1, DOK2 and REGIV are identified as the downstream molecules of the tyrosine-kinases, MEK, Her2 and FGFR1, respectively in consequence of the analysis of the correlativity between the pathways of these tyrosine-kinases and gene expression analysis. It was shown that these molecules related with the prognosis, peritoneal dissemination and the sensitivity of anticancer drug.This result may enable us to elucidate the signaling related to the biological character of gastric cancer and develop the novel molecular-targeted agent.