The study of the function of miR-128b in ESCC cells

在研究miR-128B影响食管鳞癌患者生存率的机制过程中，我们重点研究了参与细胞迁移的底物Girdin、Akt。在研究Girdin在ESCC中的作用时，有人认为Girdin也参与了ESCC的迁移。在使用ESCC标本的实验中，Girdin高表达的ESCC肿瘤往往侵袭得更深。此外，Girdin高表达的ESCC患者的5年生存率下降更为显著。因此，在ESCC中，Girdin可能是一个预后标志物，也可能是一个治疗靶点。

In the process of studying the mechanism by which miR-128b influences the survival rate of esophageal squamous cell carcinoma (ESCC) patients, we focused on Girdin, Akt substrate which is involved in the migration of cells. In the examination of the role of Girdin in ESCC, it was suggested that Girdin is involved in the migration of ESCC as well. In experiments using specimens of ESCC, ESCC tumors whose Girdin expresson is high tends to invade deeper. In addition, the 5-year survival rate of the ESCC patients whose Girdin expression is high declined more significantly. Therefore, in ESCC, Girdin may be a prognostic marker and may serve as a therapeutic target as well.