Mechanism of deteriorated recovery of cavernous nerve function with aging.

随着年龄增长海绵神经功能恢复恶化的机制。

• 批准号: 23592381
• 负责人: HISASUE Shin-ichi
• 金额: $ 3.33万
• 依托单位: Juntendo University (2013)Teikyo University (2011-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592381/
• 关键词: 再生医学; アンドロロジー; 海綿体神経; 加齢; 神経機能回復; 神経栄養因子; Neurturin; GFRa-2; 神経再生; 勃起能; 根治的前立腺摘除術; 海綿体神経機能回復; クーリッジ効果; 肥満; nNOS陽性神経

The cohabitation with female rats w/ rotation induces the recovery from ED following CN injury. We established the rehabilitation animal model using the 'Coolidge effect.' Preoperative administration of Eviprostat improved the erectile function following cavernous nerve injury, which implicated that the anti-inflammatory and anti-oxidative effect induces the early recovery of erectile function following cavernous nerve injury. Higher age has a negative impact on the nNOS-positive ganglionic neuron count in human. This result will lead to the rationale why older people show the poor outcome in their recovery of erection following radical prostatectomy.

与雌性大鼠旋转同居可促进CN损伤后ED的恢复。我们利用“柯立芝效应”建立了康复动物模型。海绵体神经损伤后，术前应用Eviprostat可改善勃起功能，提示其抗炎、抗氧化作用可促进海绵体神经损伤后勃起功能的早期恢复。增龄对人神经节细胞nNOS阳性神经元计数有负面影响。这一结果将导致为什么老年人在根治性前列腺切除术后勃起恢复方面表现出较差的结果的原因。

项目成果

Interferon-α Treatment for Growing Teratoma Syndrome of the Testis.

• DOI: 10.1159/000350897
• 发表时间: 2013-01
• 期刊: Case reports in nephrology and urology
• 作者: Inoue M;Hisasue S;Nagae M;China T;Saito K;Isotani S;Yamaguchi R;Ide H;Muto S;Horie S
• 通讯作者: Horie S

Initial experience of low energy shockwaves for the treatment of erectile dysfunction in Teikyo University Hospital, Japan

日本帝京大学医院低能量冲击波治疗勃起功能障碍的初步经验

• 发表时间: 2011
• 作者: Shin-ichi Hisasue;Hisamitsu Ide;Toshiyuki China;Satoru Muto;Raizo Yamaguchi;Shigeo Horie
• 通讯作者: Shigeo Horie

超音波を用いた腎・泌尿器領域の各臓器血 流測定とその意義 陰茎海綿体血流と勃起機能

超声测量肾、泌尿器官各器官血流量及其意义海绵体血流量与勃起功能

• 作者: 久末伸一;井手久満;吉井 隆;知名俊幸;磯谷周治;斉藤恵介;小関達郎;常盤紫野;永栄美香;山口雷蔵;武藤 智;堀江重郎;S Avirmed,Uehara H,Nakatsiji H,Fukawa T,Takemura M,Yamamoto Y,Yamaguchi K Kishimot T,Izaki H,Takahashi M,Fukumori T,Kanayama H;久末伸一;S Avilmed;Shin-ichi Hisasue;アビルメド・シーレンヤンバ;久末伸一
• 通讯作者: 久末伸一

The low-intensity shock wave therapy for erectile dysfunction: Who needs it? Who benefits from it?

低强度冲击波疗法治疗勃起功能障碍：谁需要它？

• 作者: 久末伸一;井手久満;吉井 隆;知名俊幸;磯谷周治;斉藤恵介;小関達郎;常盤紫野;永栄美香;山口雷蔵;武藤 智;堀江重郎;S Avirmed,Uehara H,Nakatsiji H,Fukawa T,Takemura M,Yamamoto Y,Yamaguchi K Kishimot T,Izaki H,Takahashi M,Fukumori T,Kanayama H;久末伸一;S Avilmed;Shin-ichi Hisasue;アビルメド・シーレンヤンバ;久末伸一;中逵弘能;久末伸一;久末伸一;久末伸一;Shin-ichi Hisasue
• 通讯作者: Shin-ichi Hisasue

Animal model for the study of the relationship between lower urinary tract symptoms/bladder outlet obstruction and erectile dysfunction

• DOI: 10.1111/j.1442-2042.2011.02823.x
• 发表时间: 2011-10-01
• 期刊: INTERNATIONAL JOURNAL OF UROLOGY
• 影响因子: 2.6
• 作者: Kobayashi, Ko;Kato, Ryuichi;Tsukamoto, Taiji
• 通讯作者: Tsukamoto, Taiji