Mechanism of deteriorated recovery of cavernous nerve function with aging.

与雌性大鼠旋转同居可促进CN损伤后ED的恢复。我们利用“柯立芝效应”建立了康复动物模型。海绵体神经损伤后，术前应用Eviprostat可改善勃起功能，提示其抗炎、抗氧化作用可促进海绵体神经损伤后勃起功能的早期恢复。增龄对人神经节细胞nNOS阳性神经元计数有负面影响。这一结果将导致为什么老年人在根治性前列腺切除术后勃起恢复方面表现出较差的结果的原因。

The cohabitation with female rats w/ rotation induces the recovery from ED following CN injury. We established the rehabilitation animal model using the 'Coolidge effect.' Preoperative administration of Eviprostat improved the erectile function following cavernous nerve injury, which implicated that the anti-inflammatory and anti-oxidative effect induces the early recovery of erectile function following cavernous nerve injury. Higher age has a negative impact on the nNOS-positive ganglionic neuron count in human. This result will lead to the rationale why older people show the poor outcome in their recovery of erection following radical prostatectomy.