Development of a Rat Model for Retrobulbar Angiography of X-Ray Computed Tomography with an Iodine-Containing Polymer

使用含碘聚合物进行 X 射线计算机断层扫描的大鼠球后血管造影模型的开发

• 批准号: 23592605
• 负责人: MATSUSHITA Kenji
• 金额: $ 3.33万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592605/
• 关键词: 医用工学; 放射光微小血管造影法; 緑内障; 眼医工学; 放射光

Recent adavances in optical coherence tomography allow visualization of the optic nerve structure. However, the infrared light source is limited in its ability to analyze the retrobulbar structure because of insufficient penetration; in contrast, X-rays can penetrate deeper. We developed a model for retrobulbar angiography with computed tomography to reveal the retrobulbar structures around the optic nerve head. Four-week-old SD rats were observed alive with CT. Trough the catheter, we had injected a contrast agent, iohexol and an iodine-containing polymer solution. After contrast agent washout, the CT values were recorded at baseline, maximal contrast agent enhancement, washout, and maximal iodine-containing polymer enhancement. We localized the area governed by ICA. The polymer stayed in the eye after the contrast was flushed from the orbit. We developed a model for retrobulbar angiography that makes it easy to adjust the imaging conditions.

光学相干断层扫描的最新进展使视神经结构的可视化成为可能。然而，由于红外光源的穿透性不足，其分析球后结构的能力受到限制；相比之下，x射线可以穿透得更深。我们开发了一个模型的球后血管造影与计算机断层显示周围的视神经头球后结构。用CT观察4周龄SD大鼠的存活情况。通过导管，我们注射了造影剂、碘己醇和含碘聚合物溶液。对比剂洗脱后，记录基线、最大对比剂增强、洗脱和最大含碘聚合物增强时的CT值。我们把ICA管辖的地区本地化了。对比剂从眼眶中冲洗出来后，聚合物留在了眼睛中。我们开发了一种便于调整成像条件的球后血管造影模型。

项目成果

One-year results of intravitreal bevacizumab as an adjunct to trabeculectomy for neovascular glaucoma

玻璃体内注射贝伐单抗作为小梁切除术辅助治疗新生血管性青光眼的一年结果

• 发表时间: 2011
• 期刊: Eye
• 影响因子: 3.9
• 作者: Miki A;Oshima Y;Otori Y;Matsushita K;Nishida K.
• 通讯作者: Nishida K.

Evaluation of the Choroidal Thickness Using High-Penetration Optical Coherence Tomography With Long Wavelength in Highly Myopic Normal-Tension Glaucoma

• DOI: 10.1016/j.ajo.2011.05.037
• 发表时间: 2012-01-01
• 期刊: AMERICAN JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.2
• 作者: Usui, Shinichi;Ikuno, Yasushi;Nishida, Kohji
• 通讯作者: Nishida, Kohji

Development of the model for rat retrobalbar angiography of X-ray CT with iode-containing polymer.

含碘聚合物 X 射线 CT 大鼠后脑血管造影模型的开发。

• 发表时间: 2013
• 作者: 平野慎一郎;阿久根陽子;重安千花;水野嘉信;望月弘嗣;山田昌和;直井信久;松下賢治
• 通讯作者: 松下賢治

Interface fluid syndrome after laser in situ keratomileusis following herpetic keratouveitis.

带状疱疹性角膜葡萄膜炎后激光原位角膜磨镶术后的界面液综合征。

• DOI: 10.1016/j.jcrs.2013.04.026
• 发表时间: 2013
• 期刊: J Cataract Refract Surg.
• 作者: Goto S;Koh S;Toda R;Soma T;Matsushita K;Maeda N;Nishida K.
• 通讯作者: Nishida K.

マウス視神経乳頭アストロサイトの単離培養法の確立

小鼠视盘星形胶质细胞分离培养方法的建立

• 发表时间: 2013
• 作者: Nishimura T;Machida S;Kondo M;Terasaki H;Yokoyama D;Kurosaka D.;河嶋瑠美
• 通讯作者: 河嶋瑠美