Development of a Rat Model for Retrobulbar Angiography of X-Ray Computed Tomography with an Iodine-Containing Polymer

光学相干断层扫描的最新进展使视神经结构可视化成为可能。然而，由于穿透不足，红外光源分析球后结构的能力受到限制；相比之下，X射线可以穿透得更深。我们开发了一种球后血管造影术的模型，利用计算机断层扫描来显示视神经头周围的球后结构。用CT观察四周龄SD大鼠的存活情况。通过导管，我们注入了造影剂、碘海醇和含碘聚合物溶液。在对比剂冲洗后，记录基线、最大对比剂增强、最大对比剂增强、最大含碘聚合物增强时的CT值。我们把ICA管辖的地区本地化了。在对比剂从轨道上冲走后，聚合物留在了眼睛里。我们开发了一种球后血管造影术模型，使成像条件的调整变得容易。

Recent adavances in optical coherence tomography allow visualization of the optic nerve structure. However, the infrared light source is limited in its ability to analyze the retrobulbar structure because of insufficient penetration; in contrast, X-rays can penetrate deeper. We developed a model for retrobulbar angiography with computed tomography to reveal the retrobulbar structures around the optic nerve head. Four-week-old SD rats were observed alive with CT. Trough the catheter, we had injected a contrast agent, iohexol and an iodine-containing polymer solution. After contrast agent washout, the CT values were recorded at baseline, maximal contrast agent enhancement, washout, and maximal iodine-containing polymer enhancement. We localized the area governed by ICA. The polymer stayed in the eye after the contrast was flushed from the orbit. We developed a model for retrobulbar angiography that makes it easy to adjust the imaging conditions.