Strategy for treatment of periodontitis with regulating exocytosis using functional bionano particle

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We explored factors for intracellular vesicle trafficking in gingival epithelial cells and examined a possibility of the regulation. A small G-protein Rab5 and the associated protein vinculin were identified as important factors for vesicle trafficking in the cells. Rab5 and ICAM-1 were associated with uptake of Porphyromonas gingivals by the cells. Furthermore, we clarified that E-selectin is important for regulating endothelial exocytosis by stimulation with P. gingivalis.