Development of infectious control by regulating endocytosis
Development of infectious control by regulating endocytosis
批准号:
22390354
负责人:
MATSUSHITA Kenji
金额:
$12.31万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们澄清了Vinculin和ICAM-1以及小g蛋白Rab5是人类细胞中细菌内吞作用的重要分子。Vinculin通过控制Rab5的活性来调节细菌内吞作用。一氧化氮(NO)也通过Rab5的s-亚硝基化调节细菌的内吞作用。这些分子可能对调节细菌内吞作用有用。
英文摘要
We clarified that Vinculin and ICAM-1 as well as a small G-protein Rab5 are important molecules to bacterial endocytosis in human cells. Vinculin regulated bacterial endocytosis via controlling activity of Rab5. Nitric oxide (NO)also regulated bacterial endocytosis by s-nitrosylation of Rab5. These molecules may be useful for regulating bacterial endocytosis.
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A MULTIDISCIPLINARY COMMUNITY CARE PROGRAM FOCUSING ON ORAL HEALTH
专注于口腔健康的多学科社区护理计划
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sakashita R, Watanabe K, Hamada M, Matsushita K, Nishitani M, Nishihira T]
通讯作者:
Nishihira T
Morroniside derivative regulates E-selectin expression in human endothelial cells
莫诺苷衍生物调节人内皮细胞中 E-选择素的表达
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tanigawa N, Takeda Y, Sunghwa F, Ninomiya M, Hagiwara M, Koketsu M, Matsushita K]
通讯作者:
Matsushita K
バルプロ酸(VPA)はERK1/2の活性化を介してHigh Mobility Group Box 1 (HMGB1)の産生を誘導する
丙戊酸 (VPA) 通过激活 ERK1/2 诱导高迁移率族盒 1 (HMGB1) 的产生
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[杉浦進介, 江口傑徳, 萩原真, 小松寿明, 谷川順美, 野口俊英, 松下健二]
通讯作者:
松下健二
バルプロ酸は HMGB1の能動放出を誘導して、エンドトキシンショックに対する感受性を高める、エンドトキシン研究14
丙戊酸诱导 HMGB1 主动释放并增加对内毒素休克的敏感性,内毒素研究 14
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[杉浦進介, 石原裕一, 小松寿明, 萩原真, 水谷大樹, 加藤佳子,野口俊英, 松下健二]
通讯作者:
松下健二
P Valproic acid increases susceptibility to endotoxin shock through enhanced release of HMGB
P 丙戊酸通过增强 HMGB 的释放来增加对内毒素休克的敏感性
DOI:
--
发表时间:
2011
期刊:
Shock
影响因子:
3.1
作者:
[Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K]
通讯作者:
Matsushita K
共 63 条
Elucidation of the mechanism of periodontal disease involved in the progression of Alzheimer's disease
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批准号:26293438
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.4万
-
财政年份:2014
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负责人:MATSUSHITA Kenji
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依托单位:
Correlation between oxidative modified protein and pathogenesis of periodontal disease
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批准号:25670888
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2013
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负责人:MATSUSHITA Kenji
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依托单位:
Development of a Rat Model for Retrobulbar Angiography of X-Ray Computed Tomography with an Iodine-Containing Polymer
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批准号:23592605
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:MATSUSHITA Kenji
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依托单位:
Strategy for treatment of periodontitis with regulating exocytosis using functional bionano particle
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批准号:21659436
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.15万
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财政年份:2009
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负责人:MATSUSHITA Kenji
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依托单位:
Development of new therapy for periodontal disease based on regulating exocytosis
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批准号:19390538
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2007
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负责人:MATSUSHITA Kenji
-
依托单位:
Analysis of new transcription factors induced by stretch force in periodontal ligament cells
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批准号:11671899
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:MATSUSHITA Kenji
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依托单位:
海外基金