Mechanism of gingival overgrowth caused by medication - Expression and role of ets transcription factor -
Mechanism of gingival overgrowth caused by medication - Expression and role of ets transcription factor -
批准号:
23592779
负责人:
MATSUMOTO Hiroko
金额:
$2.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
IL-1a increased phosphorylations of ERK, p38 MAPK, and HSP27, and expression of Ets-1 in human gingival fibroblasts. The inhibition of G1 cell cycle arrest in human gingival fibroblasts may result from an increase in phosphorylated Cdk2 and Rb proteins and decreased levels of p21 and p27 proteins by phenytoin. Because the phosphorylation of Ets-1 is controlled by cyclin, it is suggested that expressions of Ets-1 and ESE-3 by IL-1a is associated with gingival overgrowth.
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アムロジピンによる歯肉肥厚の発症機序
氨氯地平致牙龈增厚的发病机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takeuchi R, Matsumoto H, Akimoto Y, Fujii A, 佐野司, 松本裕子,竹内麗理,小野眞紀子,秋元芳明,藤井彰]
通讯作者:
松本裕子,竹内麗理,小野眞紀子,秋元芳明,藤井彰
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takeuchi R, Matsumoto H, Akimoto Y, Fujii A]
通讯作者:
Fujii A
18-alpha- glycyrrhetinic acid suppresses G1/S- phase transition and induces apoptosis in gingival fibroblast isolated from a patient that presented with nifedi- pine-induced gingival overgrowth
18-α-甘草次酸抑制 G1/S- 相变并诱导牙龈成纤维细胞凋亡,该牙龈成纤维细胞从患有硝苯地平诱导的牙龈过度生长的患者中分离出来
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Takeuchi R, Ono M, Arikawa K, Akimoto Y, Fujii A, Matsumoto H]
通讯作者:
Matsumoto H
Tentative Pharmaco- therapy for Nifedipine-induced Gin- gival Overgrowth using 18α-glycyr- rhetinic Acid
18α-甘草次酸治疗硝苯地平引起的牙龈过度生长的初步药物治疗
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Takeuchi R, Ono M, Akimoto Y, Fujii A, Matsumoto H]
通讯作者:
Matsumoto H
Inhibition of G1 Cell Cycle Arrest in Human Gingival Fibroblasts Exposed to Phenytoin
苯妥英对人牙龈成纤维细胞 G1 细胞周期停滞的抑制
DOI:
10.1111/j.1472-8206.2012.01065.x
发表时间:
2012
期刊:
Fundam Clin Pharmacol
影响因子:
--
作者:
[Takeda M, Takahashi M, Nasu M, Matsumoto S., Reiri Takeuchi,Hiroko Matsumoto, Yoshiaki Akimoto,Akira Fujii]
通讯作者:
Reiri Takeuchi,Hiroko Matsumoto, Yoshiaki Akimoto,Akira Fujii
共 9 条
Effect of intravenous anesthetic agent on inflammasome in human bronchial smooth muscle cell
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批准号:15K11325
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.83万
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财政年份:2015
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负责人:MATSUMOTO Hiroko
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依托单位:
Ets family expression in cultured cells from oral tissue
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批准号:16591895
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2004
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负责人:MATSUMOTO Hiroko
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依托单位:
Clarification of Intracellular Signal Transductions in Nifedipine-Reactive Human Gingival Fibroblasts
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批准号:11671885
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1999
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负责人:MATSUMOTO Hiroko
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依托单位:
海外基金