Mechanism of gingival overgrowth caused by medication - Expression and role of ets transcription factor -

药物引起牙龈增生的机制-ets转录因子的表达及作用-

• 批准号: 23592779
• 负责人: MATSUMOTO Hiroko
• 金额: $ 2万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592779/
• 关键词: 歯肉肥厚; 細胞増殖; 細胞周期; ets-1; フェニトイン; Ets遺伝子; IL-1α; 転写因子; 薬物性歯肉肥厚; ets遺伝子; 炎症性因子

IL-1a increased phosphorylations of ERK, p38 MAPK, and HSP27, and expression of Ets-1 in human gingival fibroblasts. The inhibition of G1 cell cycle arrest in human gingival fibroblasts may result from an increase in phosphorylated Cdk2 and Rb proteins and decreased levels of p21 and p27 proteins by phenytoin. Because the phosphorylation of Ets-1 is controlled by cyclin, it is suggested that expressions of Ets-1 and ESE-3 by IL-1a is associated with gingival overgrowth.

IL-1a增加了人牙龈成纤维细胞中ERK、p38 MAPK和HSP27的磷酸化以及Ets-1的表达。苯托英对人牙龈成纤维细胞G1细胞周期阻滞的抑制可能是由于磷酸化Cdk2和Rb蛋白的增加以及p21和p27蛋白水平的降低。由于Ets-1的磷酸化受细胞周期蛋白控制，提示IL-1a表达Ets-1和ESE-3与牙龈过度生长有关。

项目成果

アムロジピンによる歯肉肥厚の発症機序

氨氯地平致牙龈增厚的发病机制

• 发表时间: 2011
• 作者: Takeuchi R;Matsumoto H;Akimoto Y;Fujii A;佐野司;松本裕子,竹内麗理,小野眞紀子,秋元芳明,藤井彰
• 通讯作者: 松本裕子,竹内麗理,小野眞紀子,秋元芳明,藤井彰

The Mechanism of Nifedipine- induced Gingival Overgrowth

硝苯地平致牙龈增生的机制

• 发表时间: 2011
• 作者: Takeuchi R;Matsumoto H;Akimoto Y;Fujii A
• 通讯作者: Fujii A

18-alpha- glycyrrhetinic acid suppresses G1/S- phase transition and induces apoptosis in gingival fibroblast isolated from a patient that presented with nifedi- pine-induced gingival overgrowth

18-α-甘草次酸抑制 G1/S- 相变并诱导牙龈成纤维细胞凋亡，该牙龈成纤维细胞从患有硝苯地平诱导的牙龈过度生长的患者中分离出来

• 发表时间: 2014
• 作者: Takeuchi R;Ono M;Arikawa K;Akimoto Y;Fujii A;Matsumoto H
• 通讯作者: Matsumoto H

Tentative Pharmaco- therapy for Nifedipine-induced Gin- gival Overgrowth using 18α-glycyr- rhetinic Acid

18α-甘草次酸治疗硝苯地平引起的牙龈过度生长的初步药物治疗

• 发表时间: 2013
• 作者: Takeuchi R;Ono M;Akimoto Y;Fujii A;Matsumoto H
• 通讯作者: Matsumoto H

Inhibition of G1 Cell Cycle Arrest in Human Gingival Fibroblasts Exposed to Phenytoin

苯妥英对人牙龈成纤维细胞 G1 细胞周期停滞的抑制

• DOI: 10.1111/j.1472-8206.2012.01065.x
• 发表时间: 2012
• 期刊: Fundam Clin Pharmacol
• 作者: Takeda M;Takahashi M;Nasu M;Matsumoto S.;Reiri Takeuchi，Hiroko Matsumoto， Yoshiaki Akimoto，Akira Fujii
• 通讯作者: Reiri Takeuchi，Hiroko Matsumoto， Yoshiaki Akimoto，Akira Fujii