Quantitative elucidation of change in fluorine associated with caries progression and inhibition

定量阐明与龋齿进展和抑制相关的氟变化

• 批准号: 23592796
• 负责人: YAMAMOTO Hiroko
• 金额: $ 3.24万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592796/
• 关键词: フッ素; 定量測定法; う蝕; 加速器; PIXE/PIGE; ＰＩＸＥ／ＰＩＧＥ; 定量測定; 脱灰; 再石灰化; PIGE; フッ素定量測定法; フッ素徐放性歯科材料; 歯質

We have developed a new fluorine quantitative measurement method using a micro-PIXE (Proton Induced X-ray Emission) / PIGE (Proton Induced Gamma-ray Emission). By using this measurement method, it has become possible for the first time to catch the movement of fluorine upon demineralization of tooth. Further, it was shown that the fluorine in the tooth released with decalcified was again taken into the tooth.The possibility that concentration value of fluorine in the tooth measured conventionally was contained both those not attached to the tooth, such as CaF2, and those attached to the tooth, has been shown.

我们开发了一种新的氟定量测量方法，使用微型PIXE（质子诱导X射线发射）/ PIGE（质子诱导γ射线发射）。通过使用这种测量方法，它已成为可能的第一次捕捉氟的运动时，牙齿脱矿。此外，还证明了脱钙后释放的牙齿中的氟再次被吸收到牙齿中，并证明了常规测量的牙齿中的氟浓度值包含CaF 2等未附着在牙齿上的氟和附着在牙齿上的氟的可能性。

项目成果

Fluorine analysis of human dentin surrounding resin composite after fluoride application by μ-PIGE/PIXE analysis

• DOI: 10.1016/j.nimb.2011.02.063
• 发表时间: 2011-10-15
• 期刊: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
• 影响因子: 1.3
• 作者: Okuyama, Katsushi;Komatsu, Hisanori;Sano, Hidehiko
• 通讯作者: Sano, Hidehiko

Measurement of fluorine distribution in carious enamel around 1.5-year aged fluoride-containing materials

1.5 年龄含氟材料周围龋齿釉质中氟分布的测量

• 发表时间: 2012
• 期刊: JAEA Takasaki Annual Report 2010 JAEA-Review
• 作者: 坂上雄樹;竹中彰治;大墨竜也;寺尾豊;興地隆史;H. Komatsu et al
• 通讯作者: H. Komatsu et al

Fluorine analysis of human enamel around fluoride-containing materials under different pH-cycling by l-PIGE/PIXE system

l-PIGE/PIXE系统在不同pH循环下对含氟材料周围的人牙釉质进行氟分析

• 发表时间: 2011
• 期刊: Nucl Instr and Meth
• 作者: Komatsu H;Yamamoto H;Matsuda M;Kijimura T;Kinugawa M. Okuyama K;Nomachi M;Yasuda K;Satoh T;Oikawa S.
• 通讯作者: Oikawa S.

Validity of a portable microhardness testing system (Cariotester) for diagnosis of progression in active caries lesions

便携式显微硬度测试系统（Cariotester）用于诊断活动性龋齿病变进展的有效性

• 发表时间: 2013
• 期刊: Dent Mater J
• 影响因子: 2.5
• 作者: Iwami Y;Yamamoto H;Hayashi M.
• 通讯作者: Hayashi M.

Comparison of Two Fluoride Regimens on Fluorine Uptake in Carious Enamel during pH-cycling

pH 循环过程中两种氟化方案对龋齿牙釉质氟吸收的比较

• 发表时间: 2012
• 期刊: JAEA Takasaki Annual Report 2011 JAEA-Review
• 作者: H. Komatsu ;Y. Matsuda ;S. Ooki ;N. Hasimoto ;K. Okuyama ;H. Yamamoto ;Y. Iwami ;S. Ebisu ;M. Nomachi ;K. Yasuda ;T. Satoh and M. Kohka
• 通讯作者: T. Satoh and M. Kohka