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Development of self-etching primer adhesive containing amino acid derivative monomer

含氨基酸衍生物单体自蚀底胶粘合剂的研制

基本信息

批准号：
16591911
负责人：
TORII Yasuhiro
金额：
$ 2.3万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

In this study, we investigate the availability as self-etching primer adhesive of the solution containing amino acid derivative monomer, N-acryloyl aspartic acid (N-AAsp).N-AAsp was synthesized by the reaction between acrylic chloride and DL-aspartic acid. Firstly, it was confirmed that the N-AAsp solution showed effectiveness in the bonding to dentine as a self etching primer.The addition of polymeric monomer in self-etching primer adhesive is essential due to the polymerization with resin matrix. Therefore, it is necessary that the solution to dissolve N-AAsp contains organic solvent. Our results indicated that the most suitable organic solvent was acetone and the equal weight mixture of acetone and water was the best. Next, the acetone/water solution containing lOwt% N-AAsp, TEGDMA as a polymeric monomer, camphor quinone (CQ) and N, N-dimethyl p-toluidine was prepared, and the bond strength to bovine dentin was measured when dentin was treated with the solutions containing various concentrations of TGDMA. As a result, maximum bond strength was obtained when the dentin was treated with the solution containing lOwt%N-AAsp, 5wt%TEGDMA, 41.5wt% H_2O, 41.5wt% acetone, lwt% CQ and lwt% N.N-dimethyl p-toluidine.In this study, we could find suitable chemical composition for the self-etching primer adhesive containing N-AAsp. However, our self-etching primer adhesive required using together with the bonding resin due to bad wetting ability with the resin. Therefore, further investigation is necessary for development of an excellent self-etching primer adhesive.

在这项研究中，我们研究了含有氨基酸衍生物单体n -丙烯酰天冬氨酸（N-AAsp）的溶液作为自蚀刻底漆粘合剂的有效性。以氯化丙烯酸和dl -天冬氨酸为原料合成N-AAsp。首先，证实了N-AAsp溶液作为自蚀刻底漆在牙本质上的结合效果。自蚀刻底漆胶粘剂由于与树脂基体发生聚合，必须加入聚合单体。因此，溶解N-AAsp的溶液中必须含有有机溶剂。结果表明，丙酮是最合适的有机溶剂，丙酮和水的等量混合物是最佳的有机溶剂。然后，制备了含有低浓度N- aasp、以聚单体TEGDMA、樟脑醌（CQ）和N， N-二甲基对甲苯胺的丙酮/水溶液，测定了不同浓度TGDMA溶液处理牙本质时，其与牛牙本质的结合强度。结果表明，用低浓度N-AAsp、5wt%TEGDMA、41.5wt% h2o、41.5wt%丙酮、lwt% CQ和lwt% n -二甲基对甲苯胺溶液处理牙本质时，牙本质的结合强度最大。本研究为含N-AAsp的自蚀刻底漆粘合剂找到了合适的化学成分。但是，我们的自蚀刻底漆由于与树脂的润湿能力差，需要与粘合树脂一起使用。因此，有必要进一步研究开发一种优良的自蚀刻底漆粘合剂。