Effect of Non-Surgical Periodontal Treatment on Renal Function and Glycemic Control in CKD and T2DM Japanese Elderly: A Preliminary Randomized Control Trial

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This randomized study aimed to determine the effect of non-surgical periodontal treatment on improvement of renal function/glycemic control of patients with CKD, periodontitis and T2DM. The treatment group received supragingival scaling. 2% minocycline hydrochloride treatment at baseline and biweekly for 2 months was also randomly given. The control group received only oral hygiene instruction. At baseline, 16 and 24 weeks, periodontal examination was performed, as well as measurement of renal function, and diabetes-related and inflammatory parameters. HbA1c slightly decreased in the treatment group at 16 weeks. TNF-alpha level seemed to be maintained by non-surgical periodontal treatment. However, no significant difference for all parameters was observed between the groups. Accordingly, non-surgical periodontal treatment has almost no benefit on renal function/glycemic control improvement in T2DM with CKD and periodontitis.