Effect of Non-Surgical Periodontal Treatment on Renal Function and Glycemic Control in CKD and T2DM Japanese Elderly: A Preliminary Randomized Control Trial

非手术牙周治疗对 CKD 和 T2DM 日本老年人肾功能和血糖控制的影响：初步随机对照试验

• 批准号: 23593086
• 负责人: OGAWA Hiroshi
• 金额: $ 3.24万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593086/
• 关键词: 2型糖尿病; 歯周病; 慢性腎臓病

This randomized study aimed to determine the effect of non-surgical periodontal treatment on improvement of renal function/glycemic control of patients with CKD, periodontitis and T2DM. The treatment group received supragingival scaling. 2% minocycline hydrochloride treatment at baseline and biweekly for 2 months was also randomly given. The control group received only oral hygiene instruction. At baseline, 16 and 24 weeks, periodontal examination was performed, as well as measurement of renal function, and diabetes-related and inflammatory parameters. HbA1c slightly decreased in the treatment group at 16 weeks. TNF-alpha level seemed to be maintained by non-surgical periodontal treatment. However, no significant difference for all parameters was observed between the groups. Accordingly, non-surgical periodontal treatment has almost no benefit on renal function/glycemic control improvement in T2DM with CKD and periodontitis.

本研究旨在探讨牙周非手术治疗对慢性肾脏病、牙周炎及2型糖尿病患者肾功能/血糖控制的影响。治疗组采用龈上洁治术。同时随机给予2%盐酸米诺环素基础治疗和双周治疗，疗程2个月。对照组仅接受口腔卫生指导。在基线、16周和24周时，进行牙周检查，并测量肾功能、糖尿病相关参数和炎症参数。治疗组16周时HbA1c略有下降。非手术牙周治疗可维持肿瘤坏死因子-α水平。然而，两组之间的所有参数均未观察到显著差异。因此，非手术牙周治疗对T2 DM合并慢性肾脏病和牙周炎患者的肾功能/血糖控制改善几乎没有好处。

项目成果

Population Approaches to Periodontal Health

人群对牙周健康的态度

• 发表时间: 2013
• 作者: Inagaki K;5 others;Kawakami T;Ogawa H
• 通讯作者: Ogawa H

SNPs correlated to severe periodontitis in diabetic patient

SNPs与糖尿病患者严重牙周炎的相关性

• 发表时间: 2013
• 作者: Damrongrungruang T;Hori S;Minagawa K;Ogawa H;Hanyu O;Sone H;Miyazaki H
• 通讯作者: Miyazaki H

Periodontal changes and serum resistin concentration among Japanese elderly

日本老年人牙周变化及血清抵抗素浓度

• 发表时间: 2013
• 作者: 春名一人;鈴木奈央;桝尾陽介;西原哲世;仲西宏介;山田和彦;岩元知之;藤本暁江;伊波幸作;瀬野恵衣;安忠大;入江丹佳子;廣藤卓雄;米田雅裕;山田潤一;Hiroshi Ogawa et al
• 通讯作者: Hiroshi Ogawa et al

全身健康における口腔健康

总体健康中的口腔健康

• 发表时间: 2012
• 作者: Kitamura M;Inagaki K;et al;小川祐司
• 通讯作者: 小川祐司

Association between polymorphism related type 2 diabetes mellitus and periodontitis

多态性相关2型糖尿病与牙周炎的关联

• 发表时间: 2013
• 作者: Hori-Matsumoto S;Ogawa H;Minagawa K;Sato M;Damrongrungruang T;Hanyu O;Sone H;Miyazaki H
• 通讯作者: Miyazaki H