Non-invasive, continuous measurement for intermediate metabolite and ion dynamics of skeletal muscle during muscle contraction

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The aim of this study is explore the possibility of using segmental multi-frequency bioelectrical impedance spectroscopy (S-BIS) to measure the dynamics of metabolism in human skeletal muscle. We examined the application of non-invasive measurement of water distribution using electrical property of cell membrane in skeletal muscle. During exercise, intra-cellular water rapidly increased and extra-cellular water decreased at the time of decreasing oxygenated hemoglobin in the tissue. From the results of several experiments, S-BIS has a possibility to detect the dynamics of metabolism in skeletal muscle during exercise.