De Novo Design for Creation of Artificial Cells Performing Budding and Fission

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Cell division is one of the most important phenomena in biological system. In this work, we investigated on de novo design of artificial cells which perform budding and fission through the mechanism different from the biological cell division. Synthetic cell divisions of lipid bilayer vesicles were induced by chemical signals such as a fluorescent hydrophilic organic molecule or a nonbilayer-forming synthetic lipid. Equal and unequal divisions were controllable for the artificial cells formed with liquid micro particles having amphiphiles on the surface in the presence of hydrolytically active lipid molecules.