De Novo Design for Creation of Artificial Cells Performing Budding and Fission

细胞分裂是生物系统中最重要的现象之一。在这项工作中，我们研究了人工细胞的从头设计，它通过不同于生物细胞分裂的机制进行萌发和分裂。化学信号可诱导脂质双层囊泡的合成细胞分裂，如荧光亲水性有机分子或非双层形成的合成脂类。对于表面带有两亲性的液体微粒形成的人工细胞，在具有水解性活性的脂分子存在下，均匀和不均匀的分裂是可控的。

Cell division is one of the most important phenomena in biological system. In this work, we investigated on de novo design of artificial cells which perform budding and fission through the mechanism different from the biological cell division. Synthetic cell divisions of lipid bilayer vesicles were induced by chemical signals such as a fluorescent hydrophilic organic molecule or a nonbilayer-forming synthetic lipid. Equal and unequal divisions were controllable for the artificial cells formed with liquid micro particles having amphiphiles on the surface in the presence of hydrolytically active lipid molecules.