MicroRNA expression analysis of the gastric cancer peritoneal carcinomatosis

转移机制的建立有助于改善预后。本研究旨在阐明胃癌组织中miRNA / mRNA表达谱的意义，阐明胃癌腹膜转移的机制。MiR151-5p在胃癌患者癌组织及邻近正常粘膜中的表达分析表明，MiR151-5p过表达与胃癌患者同步腹膜转移及不良预后显著相关。体外分析发现，下调miR151-5p可抑制胃癌细胞的增殖和侵袭能力。另一方面，我们已经证明脑源性神经营养因子/原肌球蛋白相关激酶B通路深入参与胃癌腹膜转移的形成。

Establishment of metastasis mechanism contributes greatly to improving prognosis. The aim of this study is to clarify the significance of miRNA / mRNA expression profile in gastric cancer tissues and to clarify the mechanism of peritoneal metastasis in gastric cancer. MiR151-5p expression analysis in cancer tissue and adjascent normal mucosa in gastric cancer patientsdemonstrated that overexpression of miR151-5p was significantly correlated with synchronous peritoneal metastasis and poor prognosis in gastric cancer patients. In vitro analysis,downregulation of miR151-5p suppressed the proliferation and invasive ability in gastric cancer cells. On the other hand, we have demonstrated that brain derived neurotrophic factor / tropomyosin-related kinase B pathway is deeply involved in the formation of peritonealmetastasis in the gastric cancer.