The elucidation of the novel microRNA-gene pathway regulating the peritoneal dissemination in gastric cancer

阐明调节胃癌腹膜播散的新型 microRNA 基因途径

• 批准号: 23791550
• 负责人: IWATSUKI Masaaki
• 金额: $ 2.66万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791550/
• 关键词: microRNA; 胃癌; 腹膜播種; 転移; 化学療法耐性; exosome; 消化器癌; miR-21

The prognosis of the patients with peritoneal dissemination of gastric cancer still remains dismal. The molecular mechanism of peritoneal dissemination has been not elucidated. microRNA has been reported to be involved in carcinogenesis, progress, metastasis and chemo-resistance. In the current study, we aimed to reveal the novel microRNA- gene pathway in human serum samples regulating the malignant potential of gastrointestinal cancer.

腹膜播散型胃癌患者的预后仍然很差。腹膜播散的分子机制尚未阐明。已有研究表明，microRNA参与了肿瘤的发生、发展、转移和化疗耐药。在目前的研究中，我们旨在揭示人血清样本中调节胃肠癌恶性潜能的新的microRNA基因途径。

项目成果

食道癌患者と非癌患者の血清中に存在するエキソソームの microRNA 発現の比較検討

食管癌患者与非癌症患者血清外泌体中microRNA表达的比较研究

• 发表时间: 2012
• 作者: 田中洋平;渡邊雅之;蒲原英伸;志垣博信;澤山浩;藏重淳二;木下浩一;齋藤誠也;岡部弘尚;長井洋平;井田智;石本崇胤;岩槻政晃;馬場秀夫
• 通讯作者: 馬場秀夫

MIcroRNA-200B regulates epithelial to mesenchymal transition in gastric carcinoma

MIcroRNA-200B 调节胃癌上皮间质转化

• 发表时间: 2011
• 作者: Junji Kurashige ;Masayuki Watanabe;Yukiharu Hiyoshi ;Hidenobu Kamohara ;Koichi Kinoshita;Seiya Saito;Masaaki Iwatsuki;Yoshifumi Baba ;Naoko Hayashi ;Hideo Baba;Kurashige J;Kinoshita K;Nakahara O;Kurashige
• 通讯作者: Kurashige

Upregulation of ERCC1 and DPD expressions after oxaliplatin-based first-line chemotherapy for metastatic colorectal cancer.

• DOI: 10.1038/bjc.2012.502
• 发表时间: 2012-12-04
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Baba, H.;Watanabe, M.;Okabe, H.;Miyamoto, Y.;Sakamoto, Y.;Baba, Y.;Iwatsuki, M.;Chikamoto, A.;Beppu, T.
• 通讯作者: Beppu, T.

胃癌におけるmicroRNA-200familyの発現と臨床病理学的検討

microRNA-200家族在胃癌中的表达及临床病理检查

• 发表时间: 2012
• 作者: 藏重淳二;蒲原英伸;渡邊雅之;田中洋平;木下浩一;齋藤誠也;岩槻政晃;馬場祥史;馬場秀夫
• 通讯作者: 馬場秀夫

Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in esophageal squamous cell carcinoma

microRNA-223过表达在食管鳞状细胞癌中调节泛素连接酶FBXW7

• 发表时间: 2012
• 作者: Kurashige J;Watanabe M;Iwatsuki M;Baba Y;Baba H
• 通讯作者: Baba H