New stromal management to focus on senescence and induction of pancreatic mesenchymal stem cells

新的基质管理重点关注胰腺间充质干细胞的衰老和诱导

• 批准号: 23791542
• 负责人: MIYASAKA Yoshihiro
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791542/
• 关键词: 膵癌; セネセンス; 問葉系幹細胞; デスモプレジア; 癌間質相互作用; 間葉系幹細胞; desmoplasia

In pancreatic cancer tissue, few stromal cells expressed senescence markers. Senescence in stromal cells might be inhibited due to interaction between mesenchymal stem cells and normal stromal cells. The cells of intraductal papillary mucinous neoplasm of

在胰腺癌组织中，极少数间质细胞表达衰老标志物。间充质干细胞与正常基质细胞之间的相互作用可能抑制了基质细胞的衰老。胆管内乳头状黏液性肿瘤细胞

项目成果

Pirfenidoneによる膵星細胞を標的とした新しい膵癌治療の可能性

使用吡非尼酮针对胰腺星状细胞进行新的胰腺癌治疗的可能性

• 发表时间: 2012
• 作者: 小薗真吾;大内田研宙;水元一博;大塚隆生;赤川進;Ana Ines Cases;江口大樹;藤原謙次;趙茗;崔林;池永直樹;田中雅夫
• 通讯作者: 田中雅夫

Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stoma: a multi-institutional study of the Japan pancreas society.

卵巢型造口粘液性囊性肿瘤的临床病理学特征和预后：日本胰腺学会的多机构研究。

• 发表时间: 2011
• 期刊: Pancreas.
• 作者: Yamao K;Yanagisawa A;Takahashi K;Kimura W;Doi R;Fukushima N;Ohike N;Shimizu M;Hatori T;Nobukawa B;Hifumi M;Kobayashi Y;Tobita K;Tanno S;Sugiyama M;Miyasaka Y;Nakagohri T;Yamaguchi T;Hanada K;Abe H;Tada M;Fujita N;Tanaka M.
• 通讯作者: Tanaka M.

Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells

• DOI: 10.1158/0008-5472.can-12-3180
• 发表时间: 2013-04-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Kozono, Shingo;Ohuchida, Kenoki;Tanaka, Masao
• 通讯作者: Tanaka, Masao

Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer

• DOI: 10.1111/j.1349-7006.2011.02113.x
• 发表时间: 2012-01
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: Ming Zhao;Y. Tominaga;K. Ohuchida;K. Mizumoto;Lin Cui;S. Kozono;H. Fujita;Ryo Maeyama;H. Toma;Masao Tanaka

Invasive Carcinoma Derived From Intestinal-Type Intraductal Papillary Mucinous Neoplasm Is Associated With Minimal Invasion, Colloid Carcinoma, and Less Invasive Behavior, Leading to a Better Prognosis

• DOI: 10.1097/mpa.0b013e318214fa86
• 发表时间: 2011-05-01
• 期刊: PANCREAS
• 影响因子: 2.9
• 作者: Nakata, Kohei;Ohuchida, Kenoki;Oda, Yoshinao
• 通讯作者: Oda, Yoshinao