Development of novel therapeutics to inhibit cell proliferation viaPOU6F1 in ovarian clear cell carcinoma
Development of novel therapeutics to inhibit cell proliferation viaPOU6F1 in ovarian clear cell carcinoma
批准号:
23791857
负责人:
YOSHIOKA Norihito
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
ARID 1A是SWI/SNF染色质重塑复合物的成员,其成员具有螺旋和ATP酶活性,并被认为通过改变某些基因周围的染色质结构来调节这些基因的转录。ARID 1A(一种假定的肿瘤抑制因子)蛋白BAF 250 a的缺失最近被描述为卵巢透明细胞癌的常见事件。在这项研究中,我们报告说,恢复野生型ARID 1A在卵巢透明细胞癌细胞中的表达,harborARID 1A突变是足以抑制细胞增殖和增强抗癌药物的敏感性。基因表达分析鉴定了ARID 1A的几个下游靶标。我们的研究结果提供了支持ARID 1A是一个真正的肿瘤抑制基因的假设的功能证据。
英文摘要
ARID1A, a member of SWI/SNF chromatin remodeling complex, whose members have helices and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Loss of the ARID1A (a putative tumor suppressor) protein BAF250a has recently been described as a frequent event in ovarian clear cell carcinoma. In this study, we report that restoring wild-type ARID1A expression in ovarian clear cell carcinoma cells that harbor ARID1A mutations is sufficient to suppress cell proliferation and enhance anticancer agent sensitivity. Gene expression analysis identified several down stream targets of ARID1A. Our results provide functional evidence in support of the hypothesis that ARID1A is a bona fide tumor suppressor gene.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
POU6F1 is the transcription factor which may be involved in cell proliferation of clear cell adeno carcinoma of the ovary
POU6F1是可能参与卵巢透明细胞腺癌细胞增殖的转录因子
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[鈴木佳克, 松浦綾乃, 山本珠生., 吉岡 範人]
通讯作者:
吉岡 範人
DOI:
10.1111/j.1749-0774.2009.00074.x
发表时间:
2009-11
期刊:
Human Cell
影响因子:
4.3
作者:
[N. Yoshioka;N. Suzuki;A. Uekawa;K. Kiguchi;B. Ishizuka]
通讯作者:
N. Yoshioka;N. Suzuki;A. Uekawa;K. Kiguchi;B. Ishizuka
POU6F1 IS THE TRANSCRIPTION FACTOR THAT MIGHT BE INVOLVED IN CELL PROLIFERATION OF
POU6F1 是可能参与细胞增殖的转录因子
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Norihito Yoshioka, A.Tozawa-Ono, K.Kiguchi, N.Suzuki]
通讯作者:
N.Suzuki
海外基金