Development of novel therapeutics to inhibit cell proliferation viaPOU6F1 in ovarian clear cell carcinoma

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ARID1A, a member of SWI/SNF chromatin remodeling complex, whose members have helices and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Loss of the ARID1A (a putative tumor suppressor) protein BAF250a has recently been described as a frequent event in ovarian clear cell carcinoma. In this study, we report that restoring wild-type ARID1A expression in ovarian clear cell carcinoma cells that harbor ARID1A mutations is sufficient to suppress cell proliferation and enhance anticancer agent sensitivity. Gene expression analysis identified several down stream targets of ARID1A. Our results provide functional evidence in support of the hypothesis that ARID1A is a bona fide tumor suppressor gene.