Development of novel therapeutics to inhibit cell proliferation viaPOU6F1 in ovarian clear cell carcinoma

开发通过 POU6F1 抑制卵巢透明细胞癌细胞增殖的新疗法

• 批准号: 23791857
• 负责人: YOSHIOKA Norihito
• 金额: $ 2.75万
• 依托单位: St. Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791857/
• 关键词: 婦人科腫瘍学; 卵巣明細胞腺癌; POU6F1

ARID1A, a member of SWI/SNF chromatin remodeling complex, whose members have helices and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Loss of the ARID1A (a putative tumor suppressor) protein BAF250a has recently been described as a frequent event in ovarian clear cell carcinoma. In this study, we report that restoring wild-type ARID1A expression in ovarian clear cell carcinoma cells that harbor ARID1A mutations is sufficient to suppress cell proliferation and enhance anticancer agent sensitivity. Gene expression analysis identified several down stream targets of ARID1A. Our results provide functional evidence in support of the hypothesis that ARID1A is a bona fide tumor suppressor gene.

ARID 1A是SWI/SNF染色质重塑复合物的成员，其成员具有螺旋和ATP酶活性，并被认为通过改变某些基因周围的染色质结构来调节这些基因的转录。ARID 1A（一种假定的肿瘤抑制因子）蛋白BAF 250 a的缺失最近被描述为卵巢透明细胞癌的常见事件。在这项研究中，我们报告说，恢复野生型ARID 1A在卵巢透明细胞癌细胞中的表达，harborARID 1A突变是足以抑制细胞增殖和增强抗癌药物的敏感性。基因表达分析鉴定了ARID 1A的几个下游靶标。我们的研究结果提供了支持ARID 1A是一个真正的肿瘤抑制基因的假设的功能证据。

项目成果

POU6F1 is the transcription factor which may be involved in cell proliferation of clear cell adeno carcinoma of the ovary

POU6F1是可能参与卵巢透明细胞腺癌细胞增殖的转录因子

• 作者: 鈴木佳克;松浦綾乃;山本珠生.;吉岡 範人
• 通讯作者: 吉岡 範人

POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary

• DOI: 10.1111/j.1749-0774.2009.00074.x
• 发表时间: 2009-11
• 期刊: Human Cell
• 影响因子: 4.3
• 作者: N. Yoshioka;N. Suzuki;A. Uekawa;K. Kiguchi;B. Ishizuka

POU6F1 IS THE TRANSCRIPTION FACTOR THAT MIGHT BE INVOLVED IN CELL PROLIFERATION OF

POU6F1 是可能参与细胞增殖的转录因子

• 发表时间: 2011
• 作者: Norihito Yoshioka;A.Tozawa-Ono;K.Kiguchi;N.Suzuki
• 通讯作者: N.Suzuki