Investigating the mechanism of diabetes associated hearing impairment by aging.
Investigating the mechanism of diabetes associated hearing impairment by aging.
批准号:
23791896
负责人:
FUJITA Takeshi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
We aimed to investigate the pathophysiology of diabetes- associated hearing impairment in type1 diabetes using mice with diabetes. Chronologic changes in the ABR threshold shift were not significantly different between the diabetic and control groups. However, vessel walls in the modiolus of the cochleae were significantly thicker inthe diabetic group than the control group. Additionally, recovery from noise-induced injury was significantly impaired in diabetic mice. Our data suggest that diabetic cochleae are more susceptible than controls to loud noise exposure.
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Ken-ichi Nibu, Hearing impairments and cochlear changes in type1 diabetes model mice and diet-induced obesity mice
Ken-ichi Nibu,1 型糖尿病模型小鼠和饮食诱导肥胖小鼠的听力障碍和耳蜗变化
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Hitoshi Tanimoto]
通讯作者:
Hitoshi Tanimoto
Hearing impairments and cochlear changes in Type1 diabetes model mice and diet-induced obesity mice
1型糖尿病模型小鼠和饮食诱导肥胖小鼠的听力障碍和耳蜗变化
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Fujita T, Yamashita D, Katsunuma S, Tanimoto H, Hasegawa S, Nibu KI.]
通讯作者:
Nibu KI.
Hearing Function and Cochlear Morphology in Diabetes Mellitus Mice Model
糖尿病小鼠模型的听力功能和耳蜗形态
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Ken-ichi Nibu]
通讯作者:
Ken-ichi Nibu
糖尿病モデルマウスにおける聴覚障害のメカニズム
糖尿病模型小鼠听力损失的机制
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[藤田岳, 山下大介, 丹生健一]
通讯作者:
丹生健一
Vulnerability for noise injury of inner ear in diabetic model mice
糖尿病模型小鼠内耳噪声损伤的脆弱性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Hitoshi Tanimoto, Ken-ichi Nibu]
通讯作者:
Ken-ichi Nibu
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