The mechanism and effect of primal therapy and nasal histamine H1 receptor in Japanese cedar pollinosis.

初步研究证实，花粉传播开始前鼻粘膜组胺H1受体mRNA表达水平与花粉传播季节鼻症状呈正相关，花粉传播开始前鼻粘膜组胺H1受体mRNA表达水平与花粉传播季节鼻症状呈正相关。通过在小鼠中重复施用雪松花粉提取物，证实了显著诱导的抓鼻和打喷嚏的鼻部症状，产生了血清雪松花粉特异性IgE。我能够确认组胺受体在人类鼻上皮细胞培养中表达。

It was confirmed that the expression level of histamine H1 receptor mRNA in nasal mucosa was reduced significantly by the enforcement of primal therapy.We found that there was a positive correlation histamine H1 receptor mRNA expression level of nasal mucosa before the start of the pollen dispersal and nasal symptoms in pollen dispersal season. By repeating administration of cedar pollen extract in mice, it was confirmed that significantly induced nasal symptoms of scratching and nose sneezing, serum cedar pollen-specific IgE was produced. I was able to confirm that the histamine receptor was expressed in human nasal epithelial cell culture.