The mechanism and effect of primal therapy and nasal histamine H1 receptor in Japanese cedar pollinosis.

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It was confirmed that the expression level of histamine H1 receptor mRNA in nasal mucosa was reduced significantly by the enforcement of primal therapy.We found that there was a positive correlation histamine H1 receptor mRNA expression level of nasal mucosa before the start of the pollen dispersal and nasal symptoms in pollen dispersal season. By repeating administration of cedar pollen extract in mice, it was confirmed that significantly induced nasal symptoms of scratching and nose sneezing, serum cedar pollen-specific IgE was produced. I was able to confirm that the histamine receptor was expressed in human nasal epithelial cell culture.