The mechanism and effect of primal therapy and nasal histamine H1 receptor in Japanese cedar pollinosis.

结果表明，实施原始性治疗后，鼻黏膜组织中组胺H1受体mRNA的表达水平明显降低。研究发现，散粉开始前鼻黏膜组织中组胺H1受体mRNA的表达水平与散粉季节的鼻部症状呈正相关。通过对小鼠重复给予雪松花粉提取物，证实了显著引起鼻部抓挠和打喷嚏的症状，血清中产生了雪松花粉特异性的IgE。我能够证实组胺受体在人类鼻腔上皮细胞培养中表达。

It was confirmed that the expression level of histamine H1 receptor mRNA in nasal mucosa was reduced significantly by the enforcement of primal therapy.We found that there was a positive correlation histamine H1 receptor mRNA expression level of nasal mucosa before the start of the pollen dispersal and nasal symptoms in pollen dispersal season. By repeating administration of cedar pollen extract in mice, it was confirmed that significantly induced nasal symptoms of scratching and nose sneezing, serum cedar pollen-specific IgE was produced. I was able to confirm that the histamine receptor was expressed in human nasal epithelial cell culture.