Niban expression of multistep head and neck squamous cell carcinogenesis

Niban在头颈部鳞状细胞多步癌变过程中的表达

• 批准号: 23791935
• 负责人: ITO Shin
• 金额: $ 2.66万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791935/
• 关键词: 頭頸部外科学; Niban; 頭頸部癌; アポトーシス; 腫瘍マーカー; ストレス蛋白; 多段階発癌

Niban expression is most dramatically increased in the early stages of renal carcinogenesis and decline with malignant progression. The function of Niban is largely unknown. Niban is found in members of the heat-shock protein family.We demonstrated stastical examination of Niban expression in head and neck squamous cell carcinoma. There was no correlation of Niban expression with TNM status. With regard to chemotherapy and radiation treatment, there was no correlation between the level of Niban expression and preoperative treatment. There were no significant differences in survival.For we done research more efficaciously, we made the model of mouse head and neck cancer, not also human head and neck cancer. This model was possible for us to get the sample of dysplasia case to advanced carcinoma case easily.

Niban表达在肾癌发生的早期显著增加，随着恶性进展而下降。Niban的功能在很大程度上是未知的。Niban存在于热休克蛋白家族的成员中。我们对Niban在头颈部鳞状细胞癌中的表达进行了统计学检验。Niban表达与TNM状态无相关性。在化疗和放疗方面，Niban表达水平与术前治疗无相关性。两组生存率无显著差异。为了更有效地进行研究，我们制作了小鼠头颈癌模型，而不是人类头颈癌模型。该模型可方便地从非典型增生病例到晚期癌病例的标本提取。

项目成果

Usefullness of Choline-PET for the detection of residual hemangiopericytoma in the skull base:Comparsion with FDG-PET

胆碱-PET 用于检测颅底残留血管外皮细胞瘤的有用性：与 FDG-PET 的比较

• 发表时间: 2012
• 期刊: Head and Face
• 作者: Ito S;Yokoyama J;Yoshimoto H;Yazawa M;Kubota K;Hanaguri M;Ohba S;Fujimaki M;Ikeda K
• 通讯作者: Ikeda K