To elucidate the pathophysiology of sepsis-associated organ dysfunction involving the Ang/Tie2 signaling pathway

阐明涉及 Ang/Tie2 信号通路的脓毒症相关器官功能障碍的病理生理学

• 批准号: 23792091
• 负责人: WADA Takeshi
• 金额: $ 2.66万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792091/
• 关键词: 集中治療医学; 急性期医学; 血管新生関連因子; 播種性血管内凝固症候群; 臓器不全; 生体侵襲; Angiopoietin; 敗血症; 血管内皮細胞傷害

The aim of this study was to elucidate the pathophysiology of sepsis-associated organ dysfunction involving the Ang/Tie2 signaling pathway and to establish a new therapeutic strategy for treating critical illnesses, such as sepsis, severe trauma and post-cardiac arrest syndrome. I examined the relationship between organ dysfunction associated with critical illness and angiogenic factors, including VEGF, Ang and their receptors and found that Ang2 plays a pivotal role in the development of organ dysfunction due to coagulofibrinolytic abnormalities. The findings of this study have been presented at six domestic and four international conferences and have also been published by four peerreview articles.

本研究的目的是阐明脓毒症相关器官功能障碍的病理生理学，涉及Ang/Tie 2信号通路，并建立一种新的治疗策略，用于治疗危重疾病，如脓毒症，严重创伤和心脏骤停后综合征。我研究了与危重病相关的器官功能障碍与血管生成因子（包括VEGF、Ang及其受体）之间的关系，发现Ang 2在凝血纤溶异常导致的器官功能障碍的发展中起着关键作用。这项研究的结果已经在六个国内和四个国际会议上发表，并发表了四篇同行评审文章。

项目成果

外傷患者における血管新生関連因子と凝固線溶反応

创伤患者血管生成相关因素及凝血纤溶反应

• 发表时间: 2011
• 作者: 和田剛志;ジェスミン・サブリナ;丸藤哲;横田裕行
• 通讯作者: 横田裕行

Time-dependent expression of endothelin-1 in lungs and the effects of TNF-α blocking peptide on acute lung injury in an endotoxemia rat model

肺内皮素-1的时间依赖性表达及TNF-α阻断肽对内毒素血症大鼠模型急性肺损伤的影响

• 发表时间: 2011
• 作者: S. Jesmin;T. Wada;S. Zaedi;S.N. Sultana,N. Yamaguchi;Y. Iwashima;A. Sawamura;S. Gando
• 通讯作者: S. Gando

Angiogenic factors and their soluble receptors in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) in critically ill patients

危重患者急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）中的血管生成因子及其可溶性受体

• 发表时间: 2012
• 作者: Takeshi Wada;Subrina Jesmin;Satoshi Gando;Yuichiro Yanagida;Asumi Mizugaki;Hiroyuki Yokota
• 通讯作者: Hiroyuki Yokota

外傷患者におけるVEGF発現と凝固線溶反応

创伤患者VEGF表达与凝血纤溶反应

• 发表时间: 2011
• 作者: 和田剛志;丸藤哲
• 通讯作者: 丸藤哲

Angiogenic factors and their soluble receptors in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) in critically ill patients.

危重患者急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）中的血管生成因子及其可溶性受体。

• 发表时间: 2012
• 作者: 和田剛志;ジェスミン・サブリナ;丸藤哲;横田裕行;和田剛志;和田剛志;Takeshi Wada
• 通讯作者: Takeshi Wada