A study of the suppression mechanism of tongue cancer growth/ metastasis by Sprouty, the regulating factor of MAP kinase cascade.

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After examining the expression of Sprouty/Spred family in the human tongue cancer cell line, expression of Sprouty2,4 and Spred1 was expressed and each expression was induced through MAPK cascade. Among them, Sprouty2 inhibited not only the activation of MAPK induced by EGF and FGF stimulation in tongue cancer cell line but also inhibited the activation of Smad 1/5/8 due to the transforming growth factor-beta superfamily stimulation to be known as yet another cancer growth signal.Furthermore, Sprouty2 suppressed the expression of vascular epidermal growth factor (VEGF) in tongue cancer cell line, so it was suggested that Sprouty2 was associated with the suppression of the metastatic mechanism as well as the growth.