Effects of the Neutrophil Elastase on periodontal ligament cells and the clinical application of Neutrophil Elastase inhibitor to periodontal disease.

已知中性弹性蛋白酶是一种中性蛋白酶，在炎症情况下降解异物。牙周膜中的蛋白酶含量增加，降解牙周膜中的非胶原基质。本实验证实中性粒细胞弹性蛋白酶与牙周膜和骨基质的降解有关。此外，我们暗示了中性粒细胞弹性蛋白酶抑制剂抑制破骨细胞分化的可能性，此外，抑制剂抑制牙周韧带的降解。

It is known that Neutrophil Elastase is one of the neutral proteinase and it degrade foreign objects at the inflammatory situation. The proteinase increased in the periodontal ligament which supports teeth, and it degraded non-collagenous matrix of periodontal ligaments. At this experiment, we demonstrated that the neutrophil elastase related with the degradation of periodontal ligament and bone matrix. Additionally, we implied a possibility that the inhibitor of neutrophil elastase restrained the differentiation of osteoclasts, moreover, the inhibitor suppressed a degradation of periodontal ligaments.