Clarify the mechanism of prevention of oral mucositis by oral care ～ From the point of view of oxidative stress and micro organisms ～

阐明口腔护理预防口腔粘膜炎的机制～从氧化应激和微生物的角度～

• 批准号: 23792514
• 负责人: YAMANAKA Reiko
• 金额: $ 1.83万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792514/
• 关键词: 頭頸部がん; 口腔粘膜炎; 酸化ストレス

Oral mucositis is one of side effect of radiation therapy and chemotherapy. The aim of this study was to clarify the preventive mechanism of oral mucositis from the view point of oxidative stress and microorganisms. As the results, oral mucositis had no relationship with oral microorganisms, oxidative stress in plasma and general status.Moreover, oral mucositis had relationshipwith frequency of radiochemotherapy and chemotherapy more than oxidative stress in plasma. It was showed that initiation and severity of mucositis was not influenced by oxidative stress in plasma.

口腔黏膜炎是放疗和化疗的副作用之一。本研究的目的是从氧化应激和微生物的角度阐明口腔粘膜炎的预防机制。结果表明，口腔黏膜炎与口腔微生物、血浆氧化应激及一般状况无关，与放化疗次数的关系大于与血浆氧化应激的关系。结果表明，粘膜炎的发生和严重程度不受血浆中氧化应激的影响。

项目成果

Relationship Between Serum Albumin Concentration and Periodontal Condition in Head and Neck Cancer Patients

头颈癌患者血清白蛋白浓度与牙周状况的关系

• 发表时间: 2012
• 期刊: J Periodontol
• 影响因子: 4.3
• 作者: Maruyama T;Yamanaka R;Yokoi A;Ekuni D,Tomofuji T;Mizukawa N;Onoda T,Eguchi M,Morita M
• 通讯作者: Onoda T,Eguchi M,Morita M

Removal of percutaneous endoscopic jejunostomy tube

经皮内镜下空肠造口管的拔除

• 发表时间: 2012
• 作者: Reiko Yamanaka;Mami Minakuchi;Kumiko Nawachi;Takayuki Maruyama;Yoshihiko Soga,Takuo Kuboki;Manabu Morita
• 通讯作者: Manabu Morita

Relationship between Nutritional Status and Oral Condition in HNC Patients

HNC 患者营养状况与口腔状况的关系

• 发表时间: 2012
• 作者: Maruyama T;Yamanaka R;Yokoi A;Ekuni D,Tomofuji T;Mizukawa N;Onoda T;Eguchi M;Morita M
• 通讯作者: Morita M

Relationship Between Serum Albumin Concentration and Periodontal Condition in Head and Neck Cancer Patients.

头颈癌患者血清白蛋白浓度与牙周状况的关系。

• 发表时间: 2011
• 期刊: J Periodontol.
• 作者: Maruyama T;Yamanaka R;Yokoi A;Ekuni D;Tomofuji T;Mizukawa N;Onoda T;Eguchi M;Morita M.
• 通讯作者: Morita M.

Occlusion and postoperative weight change in a patient after esophagectomy: lessons from a case successful weight gain derived by restoration of occlusal support

食管切除术后患者的咬合和术后体重变化：通过恢复咬合支持而成功体重增加的案例的教训

• 发表时间: 2013
• 期刊: International Journal of Prosthodontics
• 影响因子: 2.3
• 作者: Reiko Yamanaka;Yoshihiko Soga;Mami Minakuchi;Kumiko Nawachi;Takayuki Maruyama;Takuo Kuboki;Manabu Morita
• 通讯作者: Manabu Morita