Sustainability By Advanced Chemoenzymatic Technologies

先进化学酶技术的可持续性

• 批准号: 5409496
• 负责人: Professor Dr. Andreas Liese
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5409496?language=en
• 关键词: Sustainability; Advanced; Chemoenzymatic; Technologies

Nature uses reaction sequences optimized over millions of years to produce stereoselective compounds in a highly sustainable way. The major aim of this project is to develop a multi-step reaction in a biomimetic way for the synthesis of products with a high enantio- and diastereoselectivity, starting from simple building blocks, such as an alken and a diene. As first step of the reaction sequence a homogeneously soluble macromolecular catalyst, a so-called "chemzyme", is applied. A membrane, as in nature, retains this artificial catalyst. The organic product stream is passed on to a second reactor without further purification, where a stereoselective hydrocyanation is catalyzed by a hydroxynitrile lyase. Enzymes or chemzymes will catalyze a possible third transformation step leading to functionalized cyclohexenyl with chiral sidechains. This type of structure is difficult to access by other methods in a stereocontrolled fashion and will provide new chiral building blocks for application in drugs and agrochemicals. These modification steps will also be integrated in the whole production process. This advanced chemoenzymatic technology enables the sustainable synthesis of a vast spectrum of highly diastereoselective products starting from simple materials like an alken and a diene. The multi-step synthesis will be carried out in a continuous flow reactor. By this setup the work-up protocols will be minimized. An overall sustainable synthesis is possible because of the integration of in situ product removal, recycling of the organic phase as well as recycling of the chemzymes and the enzymes. The efficient development of this advanced technology is assured by the expertise of the research teams covering the areas of technical chemistry, polymer chemistry, chemistry, and molecular/structural biology.

大自然使用数百万年来优化的反应序列，以高度可持续的方式生产立体选择性化合物。该项目的主要目的是以仿生方式开发多步反应，以合成具有高对映体和非对映体选择性的产物，从简单的结构单元开始，例如阿尔肯和二烯。作为反应顺序的第一步，应用均匀可溶的大分子催化剂，所谓的“化学酶”。自然界中的膜保留了这种人工催化剂。将有机产物流送至第二反应器而无需进一步纯化，其中通过羟基腈裂解酶催化立体选择性氢氰化。酶或化学酶将催化可能的第三转化步骤，导致具有手性侧链的官能化环己烯基。这种类型的结构很难通过其他方法以立体控制的方式获得，并将为药物和农用化学品的应用提供新的手性结构单元。这些修改步骤也将整合到整个生产过程中。这种先进的化学酶技术能够从简单的材料如阿尔肯和二烯开始可持续地合成大量高度非对映选择性的产物。多步合成将在连续流动反应器中进行。通过该设置，将最小化后处理方案。由于原位产物去除、有机相的再循环以及化学酶和酶的再循环的整合，整体可持续的合成是可能的。这一先进技术的有效开发得到了研究团队的专业知识的保证，这些研究团队涵盖了技术化学，聚合物化学，化学和分子/结构生物学领域。