Enzyme-catalyzed reactive distillation: extension to multistep chemoenzymatic processes

酶催化反应蒸馏：扩展到多步化学酶过程

• 批准号: 210092096
• 负责人: Professor Dr. Andreas Liese
• 金额: --
• 依托单位: Institut für Technische Biokatalyse V-6
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/210092096?language=en
• 关键词: Enzyme; catalyzed; reactive; distillation; extension

In our past project the general feasibility of enzymatic reactions in reactive distillation processes was demonstrated. In the next project period we aim to make a further step and to prove the feasibility of multistep chemoenzymatic reaction systems in reactive distillation processes, integrating a chemically catalyzed racemization with a biochemically catalyzed kinetic resolution. This resulting type of a dynamic resolution is highly important e.g. for the pharmaceutical production. Due to the increased complexity of the process with two parallel reactions in an integrated setup, inline analytics based on FTIR spectroscopy will be used to control strategies for this process. Overall, the implementation of multistep (chemo)enzymatic processes in a reactive distillation will be proved and described within a process model.

在我们过去的项目中，酶反应在反应蒸馏过程中的一般可行性得到了证明。 在下一个项目期间，我们的目标是进一步证明反应蒸馏过程中多步化学酶反应系统的可行性，将化学催化的外消旋化与生物化学催化的动力学拆分相结合。这种得到的动态分辨率类型对于例如药物生产是非常重要的。由于在集成装置中具有两个平行反应的过程的复杂性增加，基于FTIR光谱的在线分析将用于控制该过程的策略。总体而言，多步（化学）酶过程中的反应蒸馏的实施将被证明和描述的过程模型。

项目成果

Integration of Enzymatic Catalysts in a Continuous Reactive Distillation Column: Reaction Kinetics and Process Simulation

• DOI: 10.1021/ie502827f
• 发表时间: 2014-12
• 期刊: Industrial & Engineering Chemistry Research
• 影响因子: 4.2
• 作者: René Heils;Alexander Niesbach;Matthias Wierschem;D. Claus;Sebastian Soboll;P. Lutze;I. Smirnova

Enzymreaktoren und Prozessführung

酶反应器和过程控制

• DOI: 10.1007/978-3-662-57619-9_5
• 发表时间: 2018
• 作者: S. Kühn;A. Liese
• 通讯作者: A. Liese

Integration of Enzymatic Catalysts in a Reactive Distillation Column with Structured Packings

将酶催化剂集成到带有规整填料的反应蒸馏塔中

• DOI: 10.1021/ie300837v
• 发表时间: 2012
• 期刊: Industrial & Engineering Chemistry Research
• 影响因子: 4.2
• 作者: R. Heils;A. Sont;P. Bubenheim;A. Liese;I. Smirnova
• 通讯作者: I. Smirnova

In Situ Separation of the Chiral Target Compound (S)-2-Pentanol in Biocatalytic Reactive Distillation

• DOI: 10.1021/acs.iecr.7b01163
• 发表时间: 2017-06-07
• 期刊: INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
• 影响因子: 4.2
• 作者: Kuehn, Steffen;Sluyter, Gerrit;Liese, Andreas
• 通讯作者: Liese, Andreas

In situ production and renewal of biocatalytic coatings for use in enzymatic reactive distillation

• DOI: 10.1016/j.cej.2016.08.031
• 发表时间: 2016-12-15
• 期刊: CHEMICAL ENGINEERING JOURNAL
• 影响因子: 15.1
• 作者: Heils, Rene;Hu, Xihua;Smirnova, Irina
• 通讯作者: Smirnova, Irina