Development of general secondary nucleation model including effects of impeller shape and solution condition in industrial crystallizer

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The resuls of this study summarized as follows; (i) Using Computational Fluid Dynamics (CFD) coupled with the Lagrangian simulation of crystal particle motion, the relation between particle rising behavior from a vessel bottom and liquid flow was clarified. And the particle collision behaviors with impeller blades were quantified. (ii) A non-intrusive on-line measurements method for the initial dynamics of a series of primary nucleation based on the detection of laser light scattering induced by small crystal particles was developed. (iii) A population balance simulation method of crystallization including crystal attrition phenomenon caused by crystal particle collision with impeller blades was developed.