Development of a estimation method for difference of functional sites among splicing isoforms

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Although many kinds of splicing isoforms are produced by alternative splicing, splicing isoforms whose functions are investigated are much fewer than all known sequence data of splicing isoforms. Therefore, I developed a pipeline that can estimate a functional significance of splicing isoforms. Using the pipeline, I estimated the functional significance of splicing isoforms that lost their parts important for forming hydrophobic core and seemed not to be stable. As a result, it is suggested that about 20% of such splicing isoform are functionally significant.