Total synthesis of biologically active compounds by using asymmetricorganocatalytic reactions

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Efficient total synthesis of Anti-Influenza drug oseltamivir knownas Tamiflu was accomplished. The key process of the synthesis for applied to the industrialscale, is our originally developed asymmetric organocatalytic reactions, domino reaction,one-pot process and micro-flow reactions. In addition, efficient synthetic methods forsynthesis of zanamivir known as Relenza were discovered.