Cardiac regeneration therapy with human mesenchymal stem cells activated with angiotensin receptor blockers

人骨髓间充质干细胞转分化为心肌细胞的效率较低，可能不是理想的心肌干细胞来源。 我们推测血管紧张素受体阻滞剂可能会提高间充质干细胞的心肌转分化效率，因为它们对包括心脏在内的许多人体器官具有保护作用。血管紧张素受体阻断剂预处理骨髓间充质干细胞可显著提高体内外心肌转分化效率。血管紧张素受体阻断剂预处理间充质干细胞可提高向心肌细胞转分化的效率，并可能提高间充质干细胞移植治疗心脏干细胞的疗效。

Human bone marrow-derived mesenchymal stem cell might not be a good cardiac stem cell source, because of its low cardiomyogenic transdifferentiation efficiency. We hypothesized that angiotensin receptor blockers might improve cardiomyogenic transdifferentiation efficiency of mesenchymal stem cell because they have protective effects for many human organs including heart. Pretreatment of mesenchymal stem cells with angiotensin receptor blockers significantly increased the cardiomyogenic transdifferentiation efficiency in vitro and in vivo. The pretreatment of mesenchymal stem cells with angiotensin receptor blockers improved cardiomyogenic transdifferentiation efficiency, and might increase the efficacy of mesenchymal stem cell transplantation in cardiac stem cell therapy.