Elucidation of the role of hypothalamic Sirt1 in energy balance regulation.

为了阐明Sirt1（一种NAD^+依赖性脱乙酰酶）在调节能量平衡中的作用，我们分析了POMC或AgRP Sirt1条件性基因敲入小鼠。我们发现POMC神经元中的Sirt1通过交感神经系统刺激能量消耗，而AgRP神经元中的Sirt1抑制食物摄入，从而负调节能量平衡。同时我们发现饮食诱导的肥胖抑制了下丘脑Sirt1的功能，促进了能量正平衡。

In order to address the role of Sirt1, an NAD^+-dependent deacetylase, in regulating energy balance, we analyzed POMC or AgRP Sirt1 conditional knock-in mice. We found that Sirt1 in POMC neurons stimulates energy expenditure through sympathetic nervous system while Sirt1 in AgRP neurons suppresses food intake, thereby negatively regulating energy balance. Meanwhile we found that diet-induced obesity suppresses the function of hypothalamic Sirt1 and promotes positive energy balance.