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Elucidation of the carbohydrate recognization mechanisms by intestinal protozoa using MUC2 glycopeptides

Elucidation of the carbohydrate recognization mechanisms by intestinal protozoa using MUC2 glycopeptides
使用 MUC2 糖肽阐明肠道原生动物的碳水化合物识别机制
批准号:
23790460
负责人:
KATO Kentaro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

项目摘要

项目成果

KATO Kentaro的其他基金

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中文摘要
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英文摘要
Among intestinal protozoan parasites, Entamoeba histolytica infects large intestine and Cryptosporidium parvum infects small intestine via carbohydrates of the mucus. To elucidate the reason for this difference in the site of infections, recombinant lectins expressed in E. coli and 56 kinds of synthetic glycopeptides were prepared.However, it was difficult to obtain an active Entamoeba lectin. Therefore, a new assay using Entamoeba histolytica membrane and neo-glycoproteins was established. The reason for mouse strain-dependent susceptibility to Entamoeba histolytica infection was elucidated by using this assay.
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会议论文
シアル酸依存的な Entamoeba histolytica 感染感受性
唾液酸依赖性溶组织内阿米巴感染易感性
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Kentaro Kato, Yasuhiro Takegawa, Katherine S. Ralston, Carol A. Gilchrist, Shinjiro Hamano, William A. Petri Jr., Yasuro Shinohara]
通讯作者: Yasuro Shinohara
感染症事典
传染病百科全书
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Takano, A., Sugimori, C., Fujita, H., Kadosaka, T., Taylor, K.R., Tsubota, T., Konnai, S., Tajima, T., Sato, K., Watanabe, H., Ohnishi, M., Kawabata, H., 下川周子・濱野真二郎]
通讯作者: 下川周子・濱野真二郎
DOI: 10.1016/j.bbrc.2013.05.085
发表时间: 2013-06-28
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Kato, Kentaro, Takegawa, Yasuhiro, Ralston, Katherine S., Gilchrist, Carol A., Hamano, Shinjiro, Petri, William A., Jr., Shinohara, Yasuro]
通讯作者: Shinohara, Yasuro
Sialic acid dependent susceptibilities of three mouse strains against Entamoeba histolytica infection
三种小鼠品系对溶组织内阿米巴感染的唾液酸依赖性敏感性
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kentaro Kato, Yasuhiro Takegawa, Katherine S. Ralston, Carol A. Gilchrist, Shinjiro Hamano, William A. Petri Jr., Yasuro Shinohara, 加藤健太郎, 加藤健太郎]
通讯作者: 加藤健太郎
13
    Establishment of amino acid-capped metal nanoparticle for enhancing anti-protozoan activity
    • 批准号:
      19K22940
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.16万
    • 财政年份:
      2019
    • 负责人:
      KATO Kentaro
    • 依托单位:
    Comprehensive analyses in components of Toxoplasma dormant parasites.
    Ecology between livestock and infectious microbes to maintain food circulation
    Regulation mechanisms of pathogenicity of intestinal protozoa
    • 批准号:
      16K08761
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2016
    • 负责人:
      KATO Kentaro
    • 依托单位: