Elucidation of the carbohydrate recognization mechanisms by intestinal protozoa using MUC2 glycopeptides
Elucidation of the carbohydrate recognization mechanisms by intestinal protozoa using MUC2 glycopeptides
批准号:
23790460
负责人:
KATO Kentaro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Among intestinal protozoan parasites, Entamoeba histolytica infects large intestine and Cryptosporidium parvum infects small intestine via carbohydrates of the mucus. To elucidate the reason for this difference in the site of infections, recombinant lectins expressed in E. coli and 56 kinds of synthetic glycopeptides were prepared.However, it was difficult to obtain an active Entamoeba lectin. Therefore, a new assay using Entamoeba histolytica membrane and neo-glycoproteins was established. The reason for mouse strain-dependent susceptibility to Entamoeba histolytica infection was elucidated by using this assay.
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シアル酸依存的な Entamoeba histolytica 感染感受性
唾液酸依赖性溶组织内阿米巴感染易感性
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kentaro Kato, Yasuhiro Takegawa, Katherine S. Ralston, Carol A. Gilchrist, Shinjiro Hamano, William A. Petri Jr., Yasuro Shinohara]
通讯作者:
Yasuro Shinohara
感染症事典
传染病百科全书
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takano, A., Sugimori, C., Fujita, H., Kadosaka, T., Taylor, K.R., Tsubota, T., Konnai, S., Tajima, T., Sato, K., Watanabe, H., Ohnishi, M., Kawabata, H., 下川周子・濱野真二郎]
通讯作者:
下川周子・濱野真二郎
DOI:
10.1016/j.bbrc.2013.05.085
发表时间:
2013-06-28
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Kato, Kentaro, Takegawa, Yasuhiro, Ralston, Katherine S., Gilchrist, Carol A., Hamano, Shinjiro, Petri, William A., Jr., Shinohara, Yasuro]
通讯作者:
Shinohara, Yasuro
Sialic acid dependent susceptibilities of three mouse strains against Entamoeba histolytica infection
三种小鼠品系对溶组织内阿米巴感染的唾液酸依赖性敏感性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kentaro Kato, Yasuhiro Takegawa, Katherine S. Ralston, Carol A. Gilchrist, Shinjiro Hamano, William A. Petri Jr., Yasuro Shinohara, 加藤健太郎, 加藤健太郎]
通讯作者:
加藤健太郎
マウス腸管ムチンの糖鎖構造に関する研究
小鼠肠道粘蛋白糖链结构的研究
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kentaro Kato, Yasuhiro Takegawa, Katherine S. Ralston, Carol A. Gilchrist, Shinjiro Hamano, William A. Petri Jr., Yasuro Shinohara, 加藤健太郎, 加藤健太郎, 加藤健太郎]
通讯作者:
加藤健太郎
共 13 条
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Development of glycopeptide array aiming for diagnosis of infectious diseases
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