Analysis of maintenance and repair mechanism of the intestinal mucosa by the Notch ligand-receptor system

Notch配体-受体系统对肠黏膜的维护和修复机制分析

• 批准号: 23790776
• 负责人: MORIO Junko
• 金额: $ 2.75万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790776/
• 关键词: 炎症性腸疾患; Notchシグナル; 腸管上皮; 分化制御; 杯細胞; 大腸炎; Notchリガンド

Analysis of normal and inflamed intestinal mucosa of mice revealed that mRNA of Notch ligands, DLL1, DLL4 and JAG1, is expressed within those tissues. Further analysis by immunohistochemistry showed that DLL1 and DLL4 are surely expressed in intestinal epithelial cells. Targeted disruption of DLL1 and DLL4 in intestinal stem cells clearly shifted the differentiation of intestinal epithelial cells towards secretory lineage cells, which clearly demonstrated that DLL1 and DLL4 surely has an indispensable functional role within the intestinal epithelium.

对小鼠的正常和发炎的肠粘膜的分析表明，在这些组织中表达了Notch配体DLL1，DLL4和JAG1的mRNA。通过免疫组织化学的进一步分析表明，DLL1和DLL4肯定在肠上皮细胞中表达。肠道干细胞中DLL1和DLL4的靶向破坏清楚地将肠上皮细胞的分化转移到了分泌的谱系细胞上，这清楚地表明，DLL1和DLL4肯定在肠上皮中具有不可或缺的功能作用。

项目成果

Serological test and vaccinations for Measles, Mumps, Rubella, and Varicella Zoster deserve considerations as early as possible after diagnosis of Inflammatory Bowel Disease.

诊断炎症性肠病后，应尽早考虑麻疹、腮腺炎、风疹和水痘带状疱疹的血清学检测和疫苗接种。

• 发表时间: 2011
• 作者: Naganuma M;Nagahori M;Fujii T;Akiyama J;Saito E;Watanabe M
• 通讯作者: Watanabe M

術後に判明した空腸異所性膵炎の一例

术后发现空肠异位胰腺炎1例

• 发表时间: 2011
• 作者: 鈴木康平;秋山純子;藤井俊光;櫻井 幸;福田将義;吉野耕平;竹中健人;東 正新;鈴木伸治;長堀正和;長沼 誠;坂本直哉;渡辺 守;小林宏寿;杉原健一;伊藤栄作;三浦圭子
• 通讯作者: 三浦圭子

IBD患者における風疹・麻疹・水痘・ムンプスに対する抗体価測定の意義

测量 IBD 患者风疹、麻疹、水痘和腮腺炎抗体滴度的意义

• 发表时间: 2011
• 作者: 長沼 誠;長堀正和;藤井俊光;秋山純子;齋藤詠子;渡辺 守
• 通讯作者: 渡辺 守

Histological Diagnosis ofFollicular Lymphoma by Biopsy of SmallIntestinal Normal Mucosa

小肠正常粘膜活检滤泡性淋巴瘤的组织学诊断

• DOI: 10.1111/j.1443-1661.2012.01386.x
• 发表时间: 2012
• 期刊: Dig Endosc
• 作者: Okada E;Araki A;Suzuki S;Watanabe H;Ikeda T;Watanabe T;Kurata M;EishiY;Watanabe M
• 通讯作者: Watanabe M

Notch pathway and TNF-a synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine

Notch通路和TNF-a协同上调人肠道发炎粘膜中OLFM4的表达

• 发表时间: 2012
• 作者: Ryuichi Okamoto;Morio-Akiyama Junko;Hiromichi Shimizu;Tatsuro Murano;Go Ito;Satoru Fujii;Kiichiro Tsuchiya;Tetsuya Nakamura;Mamoru Watanabe
• 通讯作者: Mamoru Watanabe