The new strategy for protection of cardiomyocyte injury using HMGB1 knock out mouse

HMGB1敲除小鼠保护心肌细胞损伤的新策略

• 批准号: 23790866
• 负责人: SUZUKI Satoshi
• 金额: $ 2.75万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790866/
• 关键词: 心筋梗塞後リモデリング; 心筋細胞再生; HMGB1; 心筋梗塞; 血管新生; GFPマウス; 放射線照射; 骨髄抑制

Because we could not get the results which we hypothesized previously, we have improved some points of research methods. We clarified that the blood concentration of high mobility group box protein 1 (HMGB1) increased rapidly in a few days after myocardial infarction (MI), therefore we have decided to hasten the harvest point of heart after MI creation. Moreover, mortality was high in the first protocol, and we increased the number of transfection cells in order to increase the survival rate. We are currently in progress experiments.

由于我们不能得到先前假设的结果，我们改进了一些研究方法。我们明确了高迁移率族蛋白1(HMGB1)在心肌梗死(MI)后的几天内迅速升高，因此我们决定在MI建立后加快心脏的采集点。此外，第一种方案的死亡率很高，为了提高存活率，我们增加了转染细胞的数量。我们目前正在进行实验。

项目成果

Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction.

• DOI: 10.1371/journal.pone.0053133
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Suzuki S;Shishido T;Funayama A;Netsu S;Ishino M;Kitahara T;Sasaki T;Katoh S;Otaki Y;Watanabe T;Shibata Y;Mantovani A;Takeishi Y;Kubota I
• 通讯作者: Kubota I

Overnight beneficial impacts of adaptive servo ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in chronic heart failure patients with Cheyne-Stokes respiration

适应性伺服通气对伴有潮式呼吸的慢性心力衰竭患者的心脏超负荷、交感神经活动和心肌损伤的夜间有益影响

• 发表时间: 2012
• 作者: Suzuki S;Yoshihisa A;Miyata M;Sugimoto K;Kunii H;Yamaki T;Nakazato K;Suzuki H;Saitoh S;Takeishi Y
• 通讯作者: Takeishi Y

Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm

左心室成形术改善了一例 takotsubo 心肌病伴持续性动脉瘤的心功能

• DOI: 10.1016/j.jccase.2012.12.007
• 发表时间: 2013
• 期刊: Journal of Cardiology Cases
• 作者: Miyata M;Nakazato K;Sakamoto N;Suzuki S;Kamiyama Y;Suzuki H;Saitoh S;Takeishi Y
• 通讯作者: Takeishi Y

循環器領域における睡眠呼吸障害のガイドラインを検証する：心不全の治療

验证心血管领域睡眠呼吸障碍指南：心力衰竭的治疗

• 发表时间: 2012
• 作者: 義久精臣;鈴木 聡;竹石恭知
• 通讯作者: 竹石恭知

Effect of pentraxin 3 on pressure overload-induced left ventricular hypertrophy

五聚蛋白 3 对压力超负荷引起的左心室肥厚的影响

• 发表时间: 2012
• 作者: Suzuki S;Shishido T;Funayama A;Netsu S;Takeishi Y
• 通讯作者: Takeishi Y