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The new strategy for protection of cardiomyocyte injury using HMGB1 knock out mouse

The new strategy for protection of cardiomyocyte injury using HMGB1 knock out mouse
HMGB1敲除小鼠保护心肌细胞损伤的新策略
批准号:
23790866
负责人:
SUZUKI Satoshi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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项目成果

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中文摘要
翻译
由于我们不能得到我们先前假设的结果,我们改进了一些研究方法。我们阐明了高迁移率族蛋白1(HMGB1)的血液浓度在心肌梗死(MI)后几天内迅速增加,因此我们决定在MI后加快心脏的收获点。此外,在第一个方案中死亡率很高,我们增加了转染细胞的数量以提高存活率。我们目前正在进行实验。
英文摘要
Because we could not get the results which we hypothesized previously, we have improved some points of research methods. We clarified that the blood concentration of high mobility group box protein 1 (HMGB1) increased rapidly in a few days after myocardial infarction (MI), therefore we have decided to hasten the harvest point of heart after MI creation. Moreover, mortality was high in the first protocol, and we increased the number of transfection cells in order to increase the survival rate. We are currently in progress experiments.
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DOI: 10.1371/journal.pone.0053133
发表时间: 2013
期刊: PloS one
影响因子: 3.7
作者: [Suzuki S, Shishido T, Funayama A, Netsu S, Ishino M, Kitahara T, Sasaki T, Katoh S, Otaki Y, Watanabe T, Shibata Y, Mantovani A, Takeishi Y, Kubota I]
通讯作者: Kubota I
Overnight beneficial impacts of adaptive servo ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in chronic heart failure patients with Cheyne-Stokes respiration
适应性伺服通气对伴有潮式呼吸的慢性心力衰竭患者的心脏超负荷、交感神经活动和心肌损伤的夜间有益影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Suzuki S, Yoshihisa A, Miyata M, Sugimoto K, Kunii H, Yamaki T, Nakazato K, Suzuki H, Saitoh S, Takeishi Y]
通讯作者: Takeishi Y
Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm
左心室成形术改善了一例 takotsubo 心肌病伴持续性动脉瘤的心功能
DOI: 10.1016/j.jccase.2012.12.007
发表时间: 2013
期刊: Journal of Cardiology Cases
影响因子: --
作者: [Miyata M, Nakazato K, Sakamoto N, Suzuki S, Kamiyama Y, Suzuki H, Saitoh S, Takeishi Y]
通讯作者: Takeishi Y
循環器領域における睡眠呼吸障害のガイドラインを検証する:心不全の治療
验证心血管领域睡眠呼吸障碍指南:心力衰竭的治疗
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [義久精臣, 鈴木 聡, 竹石恭知]
通讯作者: 竹石恭知
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