IL-18 receptor antagonist in the pathogenesis and treatment of inflammatory respiratory disease

IL-18受体拮抗剂在炎症性呼吸道疾病发病机制和治疗中的作用

• 批准号: 23790927
• 负责人: IMAOKA Haruki
• 金额: $ 2.66万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790927/
• 关键词: 気管支喘息; IL-18; 気道過敏性; COPD

Airway hyperresponsiveness and airway inflammatory cells accompanied with CD4+ T cells, CD8+ T cells, eosinophils, neutrophils, and macrophages were significantly increased in ovalbumin-sensitized and challenged lung-specific IL-18 transgenic mice, as compared to wild type Balb/c mice. Overexpressing the IL-18 protein in the lungs induces type 1 and type 2 cytokines and airway inflammation, and results in increasing airway hyperresponsiveness via CD4+ T cells and IL-13 in asthma.We measured serum levels of soluble IL-18 receptor complex (sIL-18R) in patients with allergic asthma. We obtained sera from age-matched 19 allergic asthmatic subjects, 14allergic non-asthmatic subjects, and 14 healthy controls. The serum levels of sIL-18R in allergic asthmatics (32.9±4.3 ng/ml) were significantly higher than those in non-asthmatic allergic subjects (18.8±1.5 ng/ml) and healthy controls (16.1±1.6 ng/ml). In the entire population, there was a significant correlation between serum sIL-18R evels and the levels of IgE. Therefore, sIL-18R may play an important role in the inflammatory process of allergic asthma.

与野生型BALB/小鼠相比，气道高反应性和气道炎性细胞伴随CD4+ T细胞，伴随CD4+ T细胞，CD8+ T细胞，嗜酸性粒细胞，中性粒细胞和巨噬细胞伴随着卵蛋白敏感的肺敏感和挑战性的IL-18转基因小鼠，与野生型BALB/型BALB/型BALB/型BALB/型BALB/小鼠相比，显着增加。过表达肺IL-18蛋白会诱导1型和2型细胞因子和气道炎症，并导致通过CD4+ T细胞通过CD4+ T细胞和哮喘中的IL-13提高气道高反应性。我们测量了ASTHMA的固体IL-18受体复合物（SIL-18R）的血清水平。我们从年龄匹配的19个过敏性哮喘受试者，14个过敏性非偶像受试者和14个健康对照中获得了血清。过敏性哮喘患者（32.9±4.3 ng/ml）中SIL-18R的血清水平明显高于非asthmasticationaltatic过敏受试者（18.8±1.5 ng/ml）和健康对照组（16.1±1.6 ng/ml）。在整个人群中，血清SIL-18R evels与IgE水平之间存在显着相关性。因此，SIL-18R可能在过敏性哮喘的炎症过程中起重要作用。

项目成果

気管支喘息患者における可溶化IL-18受容体の検討

支气管哮喘患者可溶性IL-18受体检测

• 发表时间: 2013
• 作者: Kaira;K.;Serizawa;M.;Koh;Y.;Takahashi;T.;Hanaoka;H.;Oriuchi;N.;Endo;M.;Kondo;H.;Nakajima;T.;Yamamoto;N.;今岡治樹
• 通讯作者: 今岡治樹

関節リウマチにおける可溶化IL-18受容体複合体の検討

类风湿关节炎中可溶性 IL-18 受体复合物的检查

• 作者: Kaira;K;Serizawa;M.;Koh;Y.;Miura;S.;Kaira;R.;Abe;M.;Nakagawa;K.;Ohde;Y.;Okumura;T.;Murakami;H.;Tsuya;A.;Nakamura;Y.;Naito;T.;Takahashi;T.;Kondo;H.;Nakajima;T.;Endo;M.;Yamamoto;N.;今岡 治樹
• 通讯作者: 今岡 治樹

Increased Serum Levels of Soluble IL-18 Receptor Complex in Patients with Allergic Asthma

• DOI: 10.2332/allergolint.13-le-0548
• 发表时间: 2013-12-01
• 期刊: ALLERGOLOGY INTERNATIONAL
• 影响因子: 6.8
• 作者: Imaoka, Haruki;Takenaka, Shin-ichi;Hoshino, Tomoaki
• 通讯作者: Hoshino, Tomoaki

Increased serum levels of soluble IL-18 receptor complex in allergic asthma

过敏性哮喘患者血清中可溶性 IL-18 受体复合物水平升高

• 发表时间: 2013
• 作者: Akamatsu;H.;Kaira;K.;Murakami;H.;Serizawa;M.;Koh;Y.;Ono;A.;Shukuya;T.;Tsuya;A.;Nakamura;Y.;Kenmotsu;H.;Naito;T.;Takahashi;T.;Endo;M.;Harada;H.;Nakajima;T.;Yamamoto;N.;Masanobu MatsuokaHaruki Imaoka
• 通讯作者: Masanobu MatsuokaHaruki Imaoka