Expression of SHP-1 in the membrane of red blood cells in renal anemia

点击翻译按钮获取中文摘要

To elucidate mechanism of renal anemia in chronic renal failure, the expression of Src Homology-2 containing hematopoietic phosphatase-1 (SHP-1) and protein in the RBC membrane was examined in renal anemia model mice (5/6 nephrectomy). The expression of spectrin, one of the composition of RBC membrane was comfirmed and SHP-1 was also detected. However, no significant difference was observed in the expression of spectrin or SHP-1 between 5/6 nephrctomy model and control mice.